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Found 132 with Last Name = 'schostarez' and Initial = 'h'
TargetRenin(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50368278(CHEMBL1790497)
Affinity DataKi:  0.0400nMAssay Description:In vitro inhibition constants using recombinant human renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50368274(CHEMBL1790492)
Affinity DataKi:  0.0430nMAssay Description:In vitro inhibition constants using recombinant human renin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn Laboratories

Curated by ChEMBL
LigandPNGBDBM50012322(CHEMBL264524 | N-(2-Hydroxy-1,1-bis-hydroxymethyl-...)
Affinity DataKi:  0.0510nMAssay Description:In vitro inhibition of human renin by radio-immuno assay of angiotensin I (ANG I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076372(1-[(S)-2-Oxo-1-pentafluorophenylmethyl-2-(4-pyridi...)
Affinity DataKi:  14nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076341((S)-N-Methyl-3-pentafluorophenyl-2-[3-(5-thioxo-4,...)
Affinity DataKi:  18nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076338((S)-3-(4-Fluoro-phenyl)-N-methyl-2-[3-(5-thioxo-4,...)
Affinity DataKi:  100nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13614(2-(carboxymethoxy)-5-[(2S)-2-(pentylcarbamoyl)-2-[...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  220nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076367(1-[(S)-1-(4-Fluoro-benzyl)-2-oxo-2-(4-pyridin-2-yl...)
Affinity DataKi:  270nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076357((S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thi...)
Affinity DataKi:  290nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076366((S)-N-Methyl-3-(4-nitro-phenyl)-2-[3-(5-thioxo-4,5...)
Affinity DataKi:  330nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076374(1-((S)-1-Benzyl-2-oxo-2-thiomorpholin-4-yl-ethyl)-...)
Affinity DataKi:  380nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076339((S)-3-(4-Hydroxy-phenyl)-N-methyl-2-[3-(5-thioxo-4...)
Affinity DataKi:  400nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076336(1-[(S)-1-Benzyl-2-oxo-2-(4-pyrimidin-2-yl-piperazi...)
Affinity DataKi:  420nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076351((S)-3-(4-Methoxy-phenyl)-N-methyl-2-[3-(5-thioxo-4...)
Affinity DataKi:  460nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076334((S)-N-(3,4-Dimethoxy-benzyl)-3-phenyl-2-[3-(5-thio...)
Affinity DataKi:  490nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076382((S)-N-Benzyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydro-[...)
Affinity DataKi:  510nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076342(1-[(S)-1-Benzyl-2-oxo-2-(4-pyridin-2-yl-piperazin-...)
Affinity DataKi:  520nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50124517(2-Carboxymethoxy-5-(2-pentylcarbamoyl-2-{(S)-(S)-3...)
Affinity DataKi:  590nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076346(1-((S)-1-Benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)-3-(...)
Affinity DataKi:  660nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50124511(2-Carboxymethoxy-5-(2-{(S)-(S)-2-[2-(4-methoxy-phe...)
Affinity DataKi:  670nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50124514(2-Carboxymethoxy-5-[2-{(S)-2-[2-(5-mercapto-tetraz...)
Affinity DataKi:  700nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241372((S)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-...)
Affinity DataKi:  710nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076372(1-[(S)-2-Oxo-1-pentafluorophenylmethyl-2-(4-pyridi...)
Affinity DataKi:  770nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076348((S)-N-Cyclohexylmethyl-3-phenyl-2-[3-(5-thioxo-4,5...)
Affinity DataKi:  810nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076354(1-[(S)-1-Benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-...)
Affinity DataKi:  860nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50124513(2-Carboxymethoxy-5-[(S)-2-pentylcarbamoyl-2-((S)-2...)
Affinity DataKi:  870nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076364(1-((S)-1-Benzyl-2-morpholin-4-yl-2-oxo-ethyl)-3-(5...)
Affinity DataKi:  930nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076363(1-{(S)-1-Benzyl-2-[4-(4-methoxy-phenyl)-piperazin-...)
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13609(2-{4-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076358((S)-N-Isopropyl-3-phenyl-2-[3-(5-thioxo-4,5-dihydr...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50124515(2-Carboxymethoxy-5-{2-pentylcarbamoyl-2-[(S)-(S)-3...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076342(1-[(S)-1-Benzyl-2-oxo-2-(4-pyridin-2-yl-piperazin-...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076367(1-[(S)-1-(4-Fluoro-benzyl)-2-oxo-2-(4-pyridin-2-yl...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50112101(5-[2-(2-tert-Butoxycarbonylamino-3-phenyl-propiony...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241378((S)-1-(3-(benzyloxy)-1-(methylamino)-1-oxopropan-2...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076370((S)-N,N-Dimethyl-3-phenyl-2-[3-(5-thioxo-4,5-dihyd...)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13610(2-(carboxymethoxy)-5-[(2S)-2-(3-formamidopropanoic...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076341((S)-N-Methyl-3-pentafluorophenyl-2-[3-(5-thioxo-4,...)
Affinity DataKi:  3.00E+3nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076333((S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thi...)
Affinity DataKi:  3.20E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076343((S)-3-Phenyl-2-[3-(5-thioxo-4,5-dihydro-[1,3,4]thi...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13613(2-{4-[(2S)-2-({[(1S)-1-carboxy-2-phenylethyl]carba...)
Affinity DataKi:  3.40E+3nM ΔG°:  -30.9kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241376((S)-1-(2-(methylamino)-2-oxo-1-phenylethyl)-3-(5-t...)
Affinity DataKi:  4.10E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241374((S)-1-(3-cyclohexyl-1-(methylamino)-1-oxopropan-2-...)
Affinity DataKi:  4.10E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibitory activity against human protein tyrosine phosphatase 1B (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.0kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50241373((R)-1-(1-(methylamino)-1-oxo-3-phenylpropan-2-yl)-...)
Affinity DataKi:  5.30E+3nMAssay Description:Binding affinity for matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076363(1-{(S)-1-Benzyl-2-[4-(4-methoxy-phenyl)-piperazin-...)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmacia And Upjohn

Curated by ChEMBL
LigandPNGBDBM50076334((S)-N-(3,4-Dimethoxy-benzyl)-3-phenyl-2-[3-(5-thio...)
Affinity DataKi:  6.20E+3nMAssay Description:Binding affinity for matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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