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Found 146 with Last Name = 'schuler' and Initial = 'ad'
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115227(CHEMBL3609018)
Affinity DataIC50:  7nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115286(CHEMBL3609016)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  21nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  31nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  31nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  38nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50203012(1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea ...)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  60nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CVCL8-induced [35S]GTPgammaS binding after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150966(US8981106, 155 | USRE47267, Compound 155)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115215(CHEMBL3609006)
Affinity DataIC50:  81nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150973(US8981106, 163)
Affinity DataIC50:  105nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Affinity DataIC50:  121nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150812(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Affinity DataIC50:  130nMAssay Description:Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150837(US8981106, 26 | USRE47267, Compound 26)
Affinity DataIC50:  170nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  210nMAssay Description:Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Affinity DataIC50:  244nMAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release by treatment with compound 9 (IC50=586±91 nM). Briefly, human neu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Affinity DataIC50:  244nMAssay Description:Briefly, human neutrophils were suspended in HBSS− (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1×107 cells in tot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115217(CHEMBL3609005 | USRE47740, Compound 18 | USRE48547...)
Affinity DataIC50:  247nMAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release by treatment with compound 9 (IC50=586±91 nM). Briefly, human neu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115217(CHEMBL3609005 | USRE47740, Compound 18 | USRE48547...)
Affinity DataIC50:  247nMAssay Description:Briefly, human neutrophils were suspended in HBSS− (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1×107 cells in tot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150827(US8981106, 16)
Affinity DataIC50:  275nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150822(US8981106, 13 (SX-578) | USRE47267, Compound 13)
Affinity DataIC50:  277nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150969(US8981106, 159 | USRE47267, Compound 159)
Affinity DataIC50:  278nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150974(US8981106, 164)
Affinity DataIC50:  294nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115368(CHEMBL3609013)
Affinity DataIC50:  298nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115368(CHEMBL3609013)
Affinity DataIC50:  326nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  356nMAssay Description:Inhibition of CXCR2 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150821(US8981106, 12)
Affinity DataIC50:  390nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115219(CHEMBL3609003)
Affinity DataIC50:  410nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115224(CHEMBL3609021)
Affinity DataIC50:  444nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150972(US8981106, 162)
Affinity DataIC50:  520nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150887(US8981106, 76)
Affinity DataIC50:  540nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM420279(SX-626 | USRE47740, Compound 9 | USRE48547, Compou...)
Affinity DataIC50:  586nMAssay Description:Briefly, human neutrophils were suspended in HBSS− (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1×107 cells in tot...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM420279(SX-626 | USRE47740, Compound 9 | USRE48547, Compou...)
Affinity DataIC50:  586nMAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release by treatment with compound 9 (IC50=586±91 nM). Briefly, human neu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115220(CHEMBL3609002)
Affinity DataIC50:  611nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115224(CHEMBL3609021)
Affinity DataIC50:  655nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115210(CHEMBL3609011 | USRE47740, Compound 19 | USRE48547...)
Affinity DataIC50:  681nMAssay Description:Antagonist activity at CXCR1 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  730nMAssay Description:Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115220(CHEMBL3609002)
Affinity DataIC50:  733nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150832(US8981106, 21)
Affinity DataIC50:  759nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  880nMAssay Description:Antagonist activity at human CXCR1 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150977(US8981106, 157)
Affinity DataIC50:  890nMAssay Description:Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM150811(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Affinity DataIC50:  903nMAssay Description:Inhibition of CXCR1 (unknown origin) transfected with RBL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115213(CHEMBL3609008)
Affinity DataIC50:  918nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115371(CHEMBL3609012)
Affinity DataIC50:  933nMAssay Description:Antagonist activity at CXCR2 (unknown origin) transfected in RBL cells assessed as inhibition of IL-8-mediated intracellular calcium release preincub...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115221(CHEMBL3609001 | USRE47740, Compound 8 | USRE48547,...)
Affinity DataIC50:  1.00E+3nMAssay Description:An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release by treatment with compound 9 (IC50=586±91 nM). Briefly, human neu...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Syntrix Biosystems

Curated by ChEMBL
LigandPNGBDBM50115221(CHEMBL3609001 | USRE47740, Compound 8 | USRE48547,...)
Affinity DataIC50:  1.00E+3nMAssay Description:Briefly, human neutrophils were suspended in HBSS− (without Ca2+ and Mg2+) containing 10 mM HEPES and FLIPR Calcium 3 dye (3.1×107 cells in tot...More data for this Ligand-Target Pair
In DepthDetails US Patent
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