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Found 141 with Last Name = 'selk' and Initial = 'd'
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  0.690nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.00029-0.001More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  27nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.01-0.069More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  31nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.023-0.041More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  43nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  58nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(CHEMBL1255901 | Huperzine A)
Affinity DataIC50:  80nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163314(CHEMBL3793083)
Affinity DataIC50:  120nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as suppression of amyloid beta 40 production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163314(CHEMBL3793083)
Affinity DataIC50:  120nMAssay Description:Inhibition of gamma secretase (unknown origin)-mediated amyloid beta (1 to 40) production by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163314(CHEMBL3793083)
Affinity DataIC50:  130nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as suppression of amyloid beta 42 production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163314(CHEMBL3793083)
Affinity DataIC50:  130nMAssay Description:Inhibition of gamma secretase (unknown origin)-mediated amyloid beta (1 to 42) production by cell based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  190nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50197073(3-amino-7-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163313(CHEMBL3794179)
Affinity DataIC50:  360nMAssay Description:Inhibition of human gamma-secretase expressed in CHO cells assessed as suppression of amyloid beta 40 production using C100-Flag as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163313(CHEMBL3794179)
Affinity DataIC50:  400nMAssay Description:Inhibition of human gamma-secretase expressed in CHO cells assessed as suppression of amyloid beta 42 production using C100-Flag as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033519(5-[2-(4-Hydroxy-phenyl)-ethylamino]-1-(3-methyl-bu...)
Affinity DataIC50:  400nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542206(CHEMBL4640061)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  490nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033527(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  510nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033491(5-[2-(2-Chloro-phenyl)-ethylamino]-1-(3-methyl-but...)
Affinity DataIC50:  520nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033521(5-[2-(3-Chloro-phenyl)-ethylamino]-1-(3-methyl-but...)
Affinity DataIC50:  520nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163320(CHEMBL3792858)
Affinity DataIC50:  580nMAssay Description:Inhibition of human gamma-secretase expressed in CHO cells assessed as suppression of amyloid beta 40 production using C100-Flag as substrate incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50163313(CHEMBL3794179)
Affinity DataIC50:  620nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as suppression of amyloid beta 42 production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataIC50:  630nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033495(5-[2-(4-Chloro-3-trifluoromethyl-phenyl)-ethylamin...)
Affinity DataIC50:  790nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033496(5-[2-(2,4-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  790nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033512(5-[2-(3,5-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  800nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290390(Butyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pro...)
Affinity DataIC50:  920nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.69-1.2More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033510(5-[2-(3,4-Difluoro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  980nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033492(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-propyl-5,...)
Affinity DataIC50:  1.05E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033511(5-[2-(3-Methoxy-phenyl)-ethylamino]-1-(3-methyl-bu...)
Affinity DataIC50:  1.10E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542207(CHEMBL4634552)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033507(5-[2-(2,5-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  1.36E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033523(5-[2-(3,4-Dimethoxy-phenyl)-ethylamino]-1-(3-methy...)
Affinity DataIC50:  1.64E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033494(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  2.34E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50033527(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-(3-methyl...)
Affinity DataIC50:  2.50E+3nMAssay Description:The compound was tested for Butyrylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50164884(CHEMBL3799833)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as inhibition of amyloid beta 42 production by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50566539(CHEMBL4860033)
Affinity DataIC50:  2.70E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50542205(CHEMBL4643875)
Affinity DataIC50:  2.91E+3nMAssay Description:Inhibition of recombinant full-length C-terminal His6-tagged Escherichia coli DNA gyrase AB supercoiling activity using relaxed DNA as substrate prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033508(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-methyl-5,...)
Affinity DataIC50:  2.93E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033509(5-Phenethylamino-1-propyl-5,6,7,8-tetrahydro-1H-qu...)
Affinity DataIC50:  3.13E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033522(5-[2-(1H-Indol-3-yl)-ethylamino]-1-propyl-5,6,7,8-...)
Affinity DataIC50:  3.16E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033500(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-hexyl-5,6...)
Affinity DataIC50:  3.71E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033505(5-(Indan-2-ylamino)-1-propyl-5,6,7,8-tetrahydro-1H...)
Affinity DataIC50:  3.91E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290390(Butyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pro...)
Affinity DataIC50:  4.00E+3nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 3.3...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033517(1-Propyl-5-(2-pyridin-2-yl-ethylamino)-5,6,7,8-tet...)
Affinity DataIC50:  4.34E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033516(5-[2-(3,4-Dichloro-phenyl)-ethylamino]-1-(2-methyl...)
Affinity DataIC50:  5.32E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50369050(CHEMBL1743676)
Affinity DataIC50:  5.97E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50033489(5-[2-(4-Chloro-phenyl)-ethylamino]-1-methyl-5,6,7,...)
Affinity DataIC50:  6.60E+3nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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