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Found 223 with Last Name = 'shankaran' and Initial = 'k'
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148285(2-{(S)-3-[4-(2-Benzyl-thiazol-5-yl)-piperidin-1-yl...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50148286(2-{(S)-3-[4-(2-Benzyl-thiazol-5-yl)-piperidin-1-yl...)
Affinity DataIC50:  0.230nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249465((R)-2-((3S,4S)-3-((4-(2-benzylthiazol-5-yl)piperid...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249467((R)-2-((3S,4S)-3-((4-(2-benzyloxazol-5-yl)piperidi...)
Affinity DataIC50:  0.340nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404275(CHEMBL2112559)
Affinity DataIC50:  0.380nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249334((R)-2-((3S,4S)-3-((4-(2-benzylthiazol-5-yl)piperid...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404276(CHEMBL2112558)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404274(CHEMBL2112557)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249302((R)-2-((3S,4S)-3-((4-(2-benzyl-1H-imidazol-5-yl)pi...)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404272(CHEMBL2112552)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404278(CHEMBL2112560)
Affinity DataIC50:  0.730nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404277(CHEMBL2112553)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404273(CHEMBL2112556)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404280(CHEMBL2112555)
Affinity DataIC50:  1nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50404279(CHEMBL2112554)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249303((R)-2-((3S,4S)-3-((4-(2-benzylthiazol-4-yl)piperid...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249304((R)-2-((3S,4S)-3-((4-(5-benzyloxazol-2-yl)piperidi...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249466((R)-2-((3S,4S)-3-((4-(2-benzyloxazol-5-yl)piperidi...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249430((R)-2-((3S,4S)-3-((4-(5-benzylthiazol-2-yl)piperid...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249333((R)-2-((3S,4S)-3-((4-(2-benzyloxazol-5-yl)piperidi...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249429((R)-2-cyclohexyl-2-((3S,4S)-3-phenyl-4-((4-(2-phen...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249332((R)-2-((3S,4S)-3-((4-(2-benzyl-1H-imidazol-5-yl)pi...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249395((R)-2-cyclohexyl-2-((3S,4S)-3-phenyl-4-((4-(3-phen...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration of the compound against C-C chemokine receptor type 5 using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50066778(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249428((R)-2-cyclohexyl-2-((3S,4S)-3-phenyl-4-((4-(4-phen...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50249396((R)-2-cyclohexyl-2-((3S,4S)-3-phenyl-4-((4-(4-phen...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human C-C chemokine receptor type 5 assayed using [125I]-MIP-1 alpha as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50066778(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150924(4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine | CHEMBL...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150933(4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155790(CHEMBL362772 | [1,4]Oxazepan-(3E)-ylideneamine)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155790(CHEMBL362772 | [1,4]Oxazepan-(3E)-ylideneamine)
Affinity DataIC50:  160nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150933(4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155789((S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine | CH...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50066780(4-Methyl-pyrrolidin-(2E)-ylideneamine; hydrochlori...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155788(3-Propyl-[1,4]thiazepan-(5E)-ylideneamine | CHEMBL...)
Affinity DataIC50:  290nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150924(4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine | CHEMBL...)
Affinity DataIC50:  300nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155786(3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine | CHEMBL1...)
Affinity DataIC50:  310nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150935(CHEMBL365849 | Hexahydro-cyclopenta[c]pyrrol-(1Z)-...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155782(3-Isobutyl-[1,4]thiazepan-(5E)-ylideneamine | CHEM...)
Affinity DataIC50:  320nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155789((S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine | CH...)
Affinity DataIC50:  440nMAssay Description:Inhibitory concentration against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155790(CHEMBL362772 | [1,4]Oxazepan-(3E)-ylideneamine)
Affinity DataIC50:  450nMAssay Description:Inhibitory concentration against Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155787(3-Butyl-[1,4]thiazepan-(5E)-ylideneamine | CHEMBL1...)
Affinity DataIC50:  500nMAssay Description:Inhibitory concentration against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50066783(4-Ethyl-pyrrolidin-(2E)-ylideneamine; hydrochlorid...)
Affinity DataIC50:  500nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066778(5-Ethyl-4-methyl-pyrrolidin-(2E)-ylideneamine; hyd...)
Affinity DataIC50:  520nMAssay Description:Inhibitory activity against Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50155786(3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine | CHEMBL1...)
Affinity DataIC50:  590nMAssay Description:Inhibitory concentration against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50150924(4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine | CHEMBL...)
Affinity DataIC50:  600nMAssay Description:Inhibitory activity against Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150930(4-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine | CH...)
Affinity DataIC50:  610nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150928(3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine | CHEMBL...)
Affinity DataIC50:  610nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50150929(CHEMBL185441 | Octahydro-isoindol-(1Z)-ylideneamin...)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50290814(5-Chloro-3-morpholin-4-ylmethyl-3H-benzooxazol-2-o...)
Affinity DataIC50:  800nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
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