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Found 230 with Last Name = 'shaw' and Initial = 'an'
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  6.20nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220169(CHEMBL244933 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataKi:  120nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.200nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.230nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.350nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  0.590nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220180(CHEMBL243669 | N-[3-fluoro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36351(CID148124 | Docetaxel)
Affinity DataIC50:  8.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV 1b NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220195(CHEMBL243885 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181559(1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BEN...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV 2a NS5B RNA polymeraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181650(1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydro-1-...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220159(CHEMBL389589 | N-[3'-fluoro-4'-(trifluoromethyl)-1...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220185(1-(3-fluoro-4'-(trifluoromethyl)biphenyl-4-yl)urea...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220182(CHEMBL390629 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181560(3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]th...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181569(CHEMBL425221 | [3-(1,1-dioxo-1,4-dihydrobenzo[1,2,...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181589(1-(3,3-dimethylbutyl)-3-(1,1-dioxo-1,4-dihydrobenz...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)
Affinity DataIC50:  22nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181588(3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181584(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220201(CHEMBL243431 | N-[3-amino-4'-(trifluoromethyl)-4-b...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181583(3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-y...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220155(CHEMBL244697 | N-[3'-nitro-4'-(trifluoromethyl)-4-...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220176(CHEMBL242181 | N-[4-(2,2-difluoro-1,3-benzodioxol-...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181634(6-Amino-1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-di...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM30406(CHEMBL176058 | benzo[1,2,4]thiadiazine-1,1-dioxide...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181570(5-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181567(4-[3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)
Affinity DataIC50:  36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181646(1-(3-bromobenzyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM50220162(CHEMBL243883 | N-[4'-(trifluoromethyl)-4-biphenyly...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human KSP motor domain by ATPase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181666(3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50181579(6-chloro-3-(1,1-dioxo-1,2-dihydrobenzo[1,2,4]thiad...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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