Affinity DataIC50: 0.220nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.320nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 132nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 560nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 755nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataIC50: 780nMAssay Description:Displacement of [125I]MIP-1alpha to human recombinant CCR5 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of P450 2D6More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P450 1A1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P450 2C19More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of P450 2C9More data for this Ligand-Target Pair
Affinity DataEC50: 1nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose in presence of compound 14 by ...More data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.360nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 355nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.10nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataKd: 1.95nMAssay Description:Antagonist activity at NOR in mouse Neuro-2a cells assessed as inhibition of nociceptin-induced ERK phopshorylation administered for 15 mins before n...More data for this Ligand-Target Pair
Affinity DataEC50: 0.610nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 14nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.80nMAssay Description:Agonist activity at NOR in mouse Neuro-2a cells assessed as stimulation of ERK phopshorylation after 30 mins post dose by Alphascreen Surefire assayMore data for this Ligand-Target Pair