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Found 388 with Last Name = 'shimada' and Initial = 's'
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269772(CHEMBL4094573)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269769(CHEMBL4086848)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505124(CHEMBL4534333)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269780(CHEMBL4095807)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269752(CHEMBL4078903)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505140(CHEMBL4526884)
Affinity DataIC50:  1nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269783(CHEMBL4059534)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505122(CHEMBL4583880)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505146(CHEMBL4470637)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269782(CHEMBL4091437)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50149684(2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(2-...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269779(CHEMBL4069300)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Rattus norvegicus)
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of rat coagulation factor 9aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240469(CHEMBL4096341)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505121(CHEMBL4454495)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505125(CHEMBL4464831)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269756(CHEMBL4076727)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505145(CHEMBL4474892)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269781(CHEMBL4064453)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505126(CHEMBL4442519)
Affinity DataIC50:  6.30nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505147(CHEMBL4451442)
Affinity DataIC50:  7.90nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532062(CHEMBL4439812)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50274369(CHEMBL4126267)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human P2X3 receptor expressed in C6-BU-1 cells assessed as inhibition of calcium flux after 1 hr by Fluo-3AM dye based FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50274344(CHEMBL4129184)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X3 receptor expressed in C6-BU-1 cells assessed as inhibition of calcium flux after 1 hr by Fluo-3AM dye based FLIPR a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505123(CHEMBL4460939)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505118(CHEMBL4463054)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269751(CHEMBL4065330)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505136(CHEMBL4460020)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532065(CHEMBL4439493)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269753(CHEMBL4103672)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505134(CHEMBL4455039)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532072(CHEMBL4592312)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532080(CHEMBL4466162)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532066(CHEMBL4537290)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505122(CHEMBL4583880)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505135(CHEMBL4453597)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at mouse NR2B receptor expressed in HEK293 cells co-expressing NR1 subunit assessed as reduction in glutamic acid/glycine-induced...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505140(CHEMBL4526884)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532070(CHEMBL4466252)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269770(CHEMBL4065942)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240470(CHEMBL4092982 | US9969724, Example 27)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240487(CHEMBL4066380 | US9969724, Example 32)
Affinity DataIC50:  13nMAssay Description:Inhibition of human coagulation factor 9a using SPECTROFLUOR F9a as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269758(CHEMBL4103723)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50269758(CHEMBL4103723)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532078(CHEMBL4437131)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Mochida Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50240471(CHEMBL4069082 | US9969724, Example 45)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532082(CHEMBL4572081)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 3(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50532081(CHEMBL4454941)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at human P2X3 receptor expressed in rat C6BU-1 cells measured up to 3 mins by Fluo-3/AM dye-based fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505147(CHEMBL4451442)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50505124(CHEMBL4534333)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]-ifenprodil from NR2B receptor in rat brain cerebral cortex membranes incubated for 120 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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