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Found 39 with Last Name = 'shimeno' and Initial = 'h'
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataKi:  8.80nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataKi:  28nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataKi:  53nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity of the compound against schyphostatin of neutral sphingomyelinase (N-SMase) from bovine brain microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122310(((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-d...)
Affinity DataKi:  2.53E+5nMAssay Description:Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataIC50:  35nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081806(CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,...)
Affinity DataIC50:  37nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataIC50:  70nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081803(CHEMBL94840 | {1,1-Difluoro-2-[(3R,4R)-4-(6-oxo-1,...)
Affinity DataIC50:  88nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081806(CHEMBL94920 | {1,1-Difluoro-2-[(3R,4S)-4-(6-oxo-1,...)
Affinity DataIC50:  320nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataIC50:  330nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081804((Difluoro-{(1R,2S)-2-[2-(6-oxo-1,6-dihydro-purin-9...)
Affinity DataIC50:  340nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataIC50:  380nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50081807(({(1R,2S)-2-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-...)
Affinity DataIC50:  390nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in human erythrocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPurine nucleoside phosphorylase(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50214705(5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-di...)
Affinity DataIC50:  540nMAssay Description:Compound was evaluated for inhibition of PNP-catalyzed inosine phosphorylation in Cellulomonas spMore data for this Ligand-Target Pair
TargetSphingomyelin phosphodiesterase 2(Rattus norvegicus)
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration against neutral sphingomyelinase (N-Smase) from rat brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075302((3-ethynylphenyl)(difluoro)methylphosphonate | CHE...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase [1-45,48-631](Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataIC50:  4.90E+4nMAssay Description:Inhibitory activity of the compound against Acid sphingomyelinase from bovine brain microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Rattus norvegicus)
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50100341((2E,4E,6E,12E)-(8R,10S,14R)-8,10,12,14-Tetramethyl...)
Affinity DataIC50:  4.93E+4nMAssay Description:Inhibitory concentration against lysosomal neutral sphingomyelinase (N-Smase)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075306(CHEMBL151494 | {3-[bis(methylsulfonyl)amino]-4-[(E...)
Affinity DataIC50:  5.79E+4nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075313(CHEMBL150915 | [(4-Ethynyl-phenyl)-difluoro-methyl...)
Affinity DataIC50:  7.75E+4nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075310(CHEMBL357094 | [3-[bis(methylsulfonyl)amino]-4-(ph...)
Affinity DataIC50:  8.87E+4nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075305(CHEMBL149279 | [Difluoro-(4-phenylethynyl-phenyl)-...)
Affinity DataIC50:  1.28E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075309(CHEMBL150420 | [Difluoro-(3-phenylethynyl-phenyl)-...)
Affinity DataIC50:  1.36E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075303(CHEMBL150349 | [Difluoro-(3-methanesulfonylamino-4...)
Affinity DataIC50:  1.67E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075311(CHEMBL150350 | [Difluoro-(3-methanesulfonylamino-4...)
Affinity DataIC50:  1.76E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataIC50:  1.81E+5nMAssay Description:Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataIC50:  1.81E+5nMAssay Description:Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122310(((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-d...)
Affinity DataIC50:  3.77E+5nMAssay Description:Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122310(((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-d...)
Affinity DataIC50:  3.77E+5nMAssay Description:Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075314(CHEMBL151300 | difluoro{3-[(E)-2-phenylvinyl]pheny...)
Affinity DataIC50:  3.86E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122311(CHEMBL77022 | {2-[((E)-(3S,4R)-1,1-Difluoro-4-hydr...)
Affinity DataIC50:  4.00E+5nMAssay Description:Inhibitory activity of the compound against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075304(CHEMBL150295 | {Difluoro-[4-((E)-styryl)-phenyl]-m...)
Affinity DataIC50:  4.50E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075307(CHEMBL150202 | [Difluoro-(4'-methoxy-biphenyl-4-yl...)
Affinity DataIC50:  4.51E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)
Affinity DataIC50:  7.18E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50075308((Biphenyl-4-yl-difluoro-methyl)-phosphonic acid | ...)
Affinity DataIC50:  7.79E+5nMAssay Description:Inhibitory potency of the compound for the protein tyrosine phosphatase(PTP 1B)-catalyzed hydrolysis of p-nitrophenol phosphateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed