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Found 283 with Last Name = 'shimizu' and Initial = 'h'
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338903(CHEMBL1684849 | Ethyl 1-{4-[{4-chloro-2-[(2-fluoro...)
Affinity DataIC50:  0.450nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501949(CHEMBL4461851)
Affinity DataIC50:  0.490nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338880(CHEMBL1684826 | Ethyl 1-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338907(CHEMBL1684996 | Ethyl 1-{4-[{4-chloro-2-[hydroxy(2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338892(Benzyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338910(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50444549(CHEMBL3099695)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338919(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338934(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338883(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338887(CHEMBL1684833 | N-Butyl-1-{4-[{4-chloro-2-[(2-chlo...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338925(1-{4-[{4-Chloro-2-[hydroxy(2-methoxyphenyl)methyl]...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338937(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338905(CHEMBL1684994 | Ethyl 1-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275535(CHEMBL4126893)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275544(CHEMBL4127675)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275496(CHEMBL4127904)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338891(CHEMBL1684837 | Ethyl 4-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338885(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275497(CHEMBL4125850)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338916(CHEMBL1685005 | Ethyl 1-{4-[{4-chloro-2-[hydroxy(2...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501965(CHEMBL4457164)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501961(CHEMBL4456804)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338928(1-{3-[{4-Chloro-2-[(2,3-dimethoxyphenyl)hydroxymet...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275533(CHEMBL4129296)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275511(CHEMBL4128315)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338886(1-{4-[{4-Chloro-2-[(2-chlorophenyl)(hydroxy)methyl...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275494(CHEMBL4129177)
Affinity DataIC50:  4nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275543(CHEMBL4125736)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501963(CHEMBL4524587)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275514(CHEMBL4129619)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275531(CHEMBL4128167)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275517(CHEMBL4127082)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338877(1-{4-[{4-Chloro-2-[2,3-dihydro-1,4-benzodioxin-5-y...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338929(1-{4-[{4-Chloro-2-[2,3-dihydro-1,4-benzodioxin-5-y...)
Affinity DataIC50:  7nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338904(CHEMBL1684993 | Ethyl 1-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338895(CHEMBL1684841 | Ethyl(4-{4-[{4-chloro-2-[(2-chloro...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338931(1-{4-[{4-Chloro-2-[(2-chloro-3-fluorophenyl)(hydro...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275530(CHEMBL4129549)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338911(CHEMBL1685000 | Ethyl 1-{4-[{4-chloro-2-[2,3-dihyd...)
Affinity DataIC50:  10nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501959(CHEMBL4557212)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50336049(CHEMBL1669334 | N-benzyl-4-(6-(cyclopropylmethylam...)
Affinity DataIC50:  12nMAssay Description:Inhibition of purified His-tagged IKKbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275532(CHEMBL4129146)
Affinity DataIC50:  12nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275495(CHEMBL4126118)
Affinity DataIC50:  13nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50336052(CHEMBL1669337 | N-cinnamyl-4-(6-(cyclopropylmethyl...)
Affinity DataIC50:  13nMAssay Description:Inhibition of purified His-tagged IKKbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50338920(CHEMBL1685009 | Ethyl 1-{4-[{4-chloro-2-[2,3-dihyd...)
Affinity DataIC50:  13nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50275534(CHEMBL4127939)
Affinity DataIC50:  14nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fer(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50501957(CHEMBL4455220)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant N-terminal His-tagged human FER (SH2 domain to C-terminal) expressed in Escherichia coli assessed as decrease in FL-Peptide...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50336057(CHEMBL1669342 | N-(4-acetamidobenzyl)-4-(6-(cyclop...)
Affinity DataIC50:  15nMAssay Description:Inhibition of purified His-tagged IKKbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50336055(4-(6-(cyclopropylmethylamino)imidazo[1,2-b]pyridaz...)
Affinity DataIC50:  15nMAssay Description:Inhibition of purified His-tagged IKKbeta after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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