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Found 359 with Last Name = 'shiota' and Initial = 't'
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375751(CHEMBL256629)
Affinity DataIC50:  0.830nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375731(CHEMBL271288)
Affinity DataIC50:  0.890nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5447(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50386816(CHEMBL2047943)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human MPS1 expressed in Escherichia coliMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375724(CHEMBL271289)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50338593(3-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-6...)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50360457(CHEMBL1934623)
Affinity DataIC50:  3nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375732(CHEMBL271290)
Affinity DataIC50:  3.10nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433907(CHEMBL2380582)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375751(CHEMBL256629)
Affinity DataIC50:  3.20nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50:  3.60nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433906(CHEMBL2380583)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375730(CHEMBL257066)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375728(CHEMBL257062)
Affinity DataIC50:  4.10nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15913(2-pyridinecarboxamide deriv. 8c | 4-Amino-5-cyano-...)
Affinity DataIC50:  4.70nMAssay Description:Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375729(CHEMBL257064)
Affinity DataIC50:  5.10nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375731(CHEMBL271288)
Affinity DataIC50:  5.30nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375722(CHEMBL270435)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375744(CHEMBL402723)
Affinity DataIC50:  5.5nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375727(CHEMBL271725)
Affinity DataIC50:  6.10nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375745(CHEMBL403281)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target40S ribosomal protein S27(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420401(CHEMBL2089255 | US11208696, Example 31)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of Mps1-mediated p38 MAPK phosphorylation after 90 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50360459(CHEMBL1934625)
Affinity DataIC50:  7nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375751(CHEMBL256629)
Affinity DataIC50:  7.5nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433904(CHEMBL2380585)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50349102(CHEMBL1236095 | US11208696, Example 3)
Affinity DataIC50:  8nMAssay Description:Inhibition of MPS1 (unknown origin)More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375722(CHEMBL270435)
Affinity DataIC50:  8.80nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of HER2 by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50338600(CHEMBL1683974 | N-(3-chloro-4-(3-fluorobenzyloxy)p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Her-2 by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Institute For Bio-Medical Research

Curated by ChEMBL
LigandPNGBDBM50050356(2,2-Dimethyl-dodecanoic acid (5-dimethylamino-2,2,...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity of the compound against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rat liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of Her-2 by time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50360458(CHEMBL1934624)
Affinity DataIC50:  9nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375755(CHEMBL404269)
Affinity DataIC50:  9.20nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375747(CHEMBL405633)
Affinity DataIC50:  9.40nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433908(CHEMBL2380581)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433903(CHEMBL2380586)
Affinity DataIC50:  10nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  10nMAssay Description:Inhibition of EGFR phosphorylation in EGF-stimulated human A431 after 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375728(CHEMBL257062)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50338599(CHEMBL1683973 | N-(3-chloro-4-(3-fluorobenzyloxy)p...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375731(CHEMBL271288)
Affinity DataIC50:  11nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375723(CHEMBL257063)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375727(CHEMBL271725)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Shionogi Pharmaceutical Research Center

Curated by ChEMBL
LigandPNGBDBM50433902(CHEMBL2380587)
Affinity DataIC50:  12nMAssay Description:Inhibition of MPS1 (unknown origin) using biotin-labeled AGAGLARHTDDEMTGYVA as substrate after 90 mins by DELFIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375734(CHEMBL257065)
Affinity DataIC50:  12.4nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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