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Found 112 with Last Name = 'shiraki' and Initial = 'r'
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358251(CHEMBL1922344)
Affinity DataKi:  20nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358252(CHEMBL1922235)
Affinity DataKi:  31nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358252(CHEMBL1922235)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of human plasma kallikrein using chromogenic substrate S2302 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358251(CHEMBL1922344)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of human plasma kallikrein using chromogenic substrate S2302 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358252(CHEMBL1922235)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human thrombin using chromogenic substrate S2238 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358251(CHEMBL1922344)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human thrombin using chromogenic substrate S2238 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381555(CHEMBL2018097)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381548(CHEMBL2018090)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381537(CHEMBL2017954)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50246785((2E,2'E)-N,N'-(Thiodiethane-2,1-diyl)bis[3-(3,4-di...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human liver glycogen phosphorylase a in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381549(CHEMBL2018091)
Affinity DataIC50:  13nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381553(CHEMBL2018095)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35353(indole-2-carboxamide derivative, 25e (R-isomer))
Affinity DataIC50:  20nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50246632((2E,2'E)-N,N'-Pentane-1,5-diylbis[3-(3,4-dichlorop...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human liver glycogen phosphorylase a in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50246752((2E,2'E)-N,N'-(Oxydiethane-2,1-diyl)bis[3-(3,4-dic...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human liver glycogen phosphorylase a in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50246786((2E,2'E)-N,N'-(Sulfinyldiethane-2,1-diyl)bis[3-(3,...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human liver glycogen phosphorylase a in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358251(CHEMBL1922344)
Affinity DataIC50:  28.6nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381544(CHEMBL2018084)
Affinity DataIC50:  30nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358264(CHEMBL1922234)
Affinity DataIC50:  31.1nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35351(indole-2-carboxamide derivative, 25e)
Affinity DataIC50:  36nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358276(CHEMBL1922342)
Affinity DataIC50:  41.3nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358275(CHEMBL1922343)
Affinity DataIC50:  41.4nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50246788((2E,2'E)-N,N'-Butane-1,4-diylbis[3-(3,4-dichloroph...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human liver glycogen phosphorylase a in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381550(CHEMBL2018092)
Affinity DataIC50:  47nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35350(indole-2-carboxamide derivative, 25d)
Affinity DataIC50:  48nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358265(CHEMBL1922236)
Affinity DataIC50:  50.3nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358252(CHEMBL1922235)
Affinity DataIC50:  54.6nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358272(CHEMBL1922340)
Affinity DataIC50:  59.8nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358259(CHEMBL1922229)
Affinity DataIC50:  62.6nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35349(indole-2-carboxamide derivative, 25c)
Affinity DataIC50:  63nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358273(CHEMBL1922339)
Affinity DataIC50:  64.2nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35345(indole-2-carboxamide derivative, 15)
Affinity DataIC50:  68nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381539(CHEMBL2017956)
Affinity DataIC50:  70nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358261(CHEMBL1922230)
Affinity DataIC50:  73.4nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381552(CHEMBL2018094)
Affinity DataIC50:  75nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358274(CHEMBL1922341)
Affinity DataIC50:  86.1nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381551(CHEMBL2018093)
Affinity DataIC50:  92nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358254(CHEMBL1922233)
Affinity DataIC50:  99.2nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50381538(CHEMBL2017955)
Affinity DataIC50:  100nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG accumulation after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358257(CHEMBL1922226)
Affinity DataIC50:  103nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358253(CHEMBL1922240)
Affinity DataIC50:  106nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358262(CHEMBL1922231)
Affinity DataIC50:  118nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358268(CHEMBL1922239)
Affinity DataIC50:  123nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358260(CHEMBL1922228)
Affinity DataIC50:  140nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358267(CHEMBL1922238)
Affinity DataIC50:  155nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358266(CHEMBL1922237)
Affinity DataIC50:  157nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35352(indole-2-carboxamide derivative, 25e (S-isomer))
Affinity DataIC50:  160nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM50358263(CHEMBL1922232)
Affinity DataIC50:  213nMAssay Description:Inhibition of human factor 10A using chromogenic substrate S2222 by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Astellas Pharma

Curated by ChEMBL
LigandPNGBDBM35636(5-chloroindolecarboxamide, 13a)
Affinity DataIC50:  250nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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