TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Inhibition of TYK2 JH2 domain (unknown origin) by HTRF assay based Morrison titration analysisMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Bristol-Myers Squibb Research & Development
Curated by ChEMBL
Affinity DataKi: 0.0200nMAssay Description:Inhibition of fluorescein labeled probe binding to His-tagged human TYK2 pseudokinase domain (575-869 residues) by Morrison titration based HTRF assa...More data for this Ligand-Target Pair
Affinity DataKi: 0.0470nM ΔG°: -58.4kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nM ΔG°: -58.2kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.0570nM ΔG°: -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.0570nM ΔG°: -57.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.150nM ΔG°: -55.5kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nM ΔG°: -55.3kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity of compound was determined against to human cannabinoid receptor 2 in chinese hamster ovary cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.400nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.410nM ΔG°: -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.420nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 0.420nM ΔG°: -53.0kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.440nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 0.460nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 0.540nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 0.600nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.610nM ΔG°: -52.1kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.670nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetAdenylate cyclase type 4(Homo sapiens (Human))
Research And Development Division
Curated by ChEMBL
Research And Development Division
Curated by ChEMBL
Affinity DataKi: 0.880nMAssay Description:Binding affinity for dopamine receptor D2 was evaluated by the ability to displace [3H]spiperoneMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.970nM ΔG°: -50.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 0.980nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Binding affinity against human cannabinoid receptor 2 in chinese hamster ovary cells using WIN-55212-2 mesylate[57-3H]More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of LVP stimulated adenylate cyclase activity in pig kidney medullary membraneMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetVasopressin V2 receptor(Homo sapiens (Human))
Smith Kline & French Laboratories
Curated by ChEMBL
Smith Kline & French Laboratories
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Inhibition constant for vasopressin-stimulated adenylate cyclase (Vasopressin V2 receptor) of medullary membranes of human kidneyMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nM ΔG°: -49.9kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nM ΔG°: -49.7kJ/molepH: 7.4 T: 2°CAssay Description:The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i...More data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Displacement of GS-red from glucocorticoid receptor by fluorescence polarization assayMore data for this Ligand-Target Pair