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TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185854(US9163007, 185)
Affinity DataKi:  0.400nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50388878(CHEMBL1999931 | US9163007, 73)
Affinity DataKi:  0.400nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185901(US9163007, 408)
Affinity DataKi:  0.428nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185888(US9163007, 395)
Affinity DataKi:  0.5nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185899(US9163007, 406)
Affinity DataKi:  0.5nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM50388878(CHEMBL1999931 | US9163007, 73)
Affinity DataKi:  0.600nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185839(US9163007, 87)
Affinity DataKi:  0.601nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185846(US9163007, 151)
Affinity DataKi:  0.800nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185858(US9163007, 198)
Affinity DataKi:  0.800nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185858(US9163007, 198)
Affinity DataKi:  0.900nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185863(US9163007, 205)
Affinity DataKi:  0.900nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185888(US9163007, 395)
Affinity DataKi:  1nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185850(US9163007, 167)
Affinity DataKi:  1.05nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185898(US9163007, 405)
Affinity DataKi:  1.10nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185841(US9163007, 102)
Affinity DataKi:  1.20nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185855(US9163007, 189)
Affinity DataKi:  1.90nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197404(2-(2,6-dichloro-4-fluoro-phenoxy)-2-methyl-N-(5-su...)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197399(2-(2-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202094(CHEMBL375341 | N-(5-hydroxy-adamantan-2-yl)-2-(3-t...)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197418(2-(2-chloro-phenoxy)-N-(5-methanesulfonyl-adamanta...)
Affinity DataKi:  2nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185841(US9163007, 102)
Affinity DataKi:  2.10nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185846(US9163007, 151)
Affinity DataKi:  2.20nMpH: 7.5Assay Description:6 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 us...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185848(US9163007, 162)
Affinity DataKi:  2.25nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185863(US9163007, 205)
Affinity DataKi:  2.40nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197410(2-methyl-N-(5-sulfamoyl-adamantan-2-yl)-2-(2-trifl...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197403(CHEMBL393167 | N-(5-methanesulfonyl-adamantan-2-yl...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202094(CHEMBL375341 | N-(5-hydroxy-adamantan-2-yl)-2-(3-t...)
Affinity DataKi:  3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202094(CHEMBL375341 | N-(5-hydroxy-adamantan-2-yl)-2-(3-t...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197404(2-(2,6-dichloro-4-fluoro-phenoxy)-2-methyl-N-(5-su...)
Affinity DataKi:  3nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197416(2-(2-chloro-4-fluoro-phenoxy)-2-methyl-N-(5-sulfam...)
Affinity DataKi:  3nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185849(US9163007, 163)
Affinity DataKi:  3.40nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197408(2-(3-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
Affinity DataKi:  4nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202085((R)-N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluo...)
Affinity DataKi:  4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202087(CHEMBL374728 | N-[(1R,3S)-5-hydroxy-2-adamantyl]-2...)
Affinity DataKi:  4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197412(CHEMBL241711 | N-(5-carbamoylmethanesulfonyl-adama...)
Affinity DataKi:  4nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197414(2-(2-chloro-4-fluoro-phenoxy)-N-(5-methanesulfonyl...)
Affinity DataKi:  4nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202085((R)-N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluo...)
Affinity DataKi:  4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202102(CHEMBL375156 | N-(5-Hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against rat 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197399(2-(2-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
Affinity DataKi:  4nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM185894(US9163007, 401)
Affinity DataKi:  4.92nMpH: 7.5Assay Description:11 data point. Cdc7 kinase assays were carried out in 25 mM HEPES, pH 7.5, 1 mM DTT, 10 mM MgCl2, 100 μM Na3VO4, and 0.075 mg/ml Triton X-100 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202085((R)-N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluo...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202087(CHEMBL374728 | N-[(1R,3S)-5-hydroxy-2-adamantyl]-2...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202102(CHEMBL375156 | N-(5-Hydroxy-adamantan-2-yl)-2-[4-(...)
Affinity DataKi:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202105(CHEMBL218093 | N-adamantan-2-yl-2-[4-(4-chloro-phe...)
Affinity DataKi:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202093(2-[3-(2-fluoro-phenoxy)-azetidin-1-yl]-N-(5-hydrox...)
Affinity DataKi:  5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202085((R)-N-[(E)-5-hydroxy-2-adamantyl]-2-{4-[5-(trifluo...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197402(2-(4-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
Affinity DataKi:  5nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197418(2-(2-chloro-phenoxy)-N-(5-methanesulfonyl-adamanta...)
Affinity DataKi:  5nMAssay Description:Inhibition of human HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50197402(2-(4-chloro-phenoxy)-2-methyl-N-(5-sulfamoyl-adama...)
Affinity DataKi:  5nMAssay Description:Inhibition of mouse HSD1 assessed as interconversion of cortisone to cortisolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50202104((E)-N-(5-methoxy-adamantan-2-yl)-2-[4-(5-trifluoro...)
Affinity DataKi:  6nMAssay Description:Inhibition of human 11beta-HSD1 expressed in E. coli by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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