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Found 2254 with Last Name = 'shu' and Initial = 's'
TargetGlutamate carboxypeptidase 2(Homo sapiens (Human))
Eisai Research Institute

Curated by ChEMBL
LigandPNGBDBM50246899((S)-2-(3-((S)-1-carboxy-5-(4-iodobenzamido)pentyl)...)
Affinity DataKi:  0.0100nMAssay Description:Inhibition of GCP2 by top scintillation counter in presence of 30 nM NAA[3]GMore data for this Ligand-Target Pair
TargetMelanocortin receptor 4(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50151511(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity towards Melanocortin 4 receptor using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Uppsala University

Curated by ChEMBL
LigandPNGBDBM50151511(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity towards Melanocortin 4 receptor using [125I]NDP-MSHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50363990(CHEMBL1949915)
Affinity DataKi:  0.400nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50523555(CHEMBL4474284)
Affinity DataKi:  0.510nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50205990(CHEMBL395429 | OXYTOCIN)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22904((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of Histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50523556(CHEMBL4458988)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50347087(CHEMBL1796273)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347090(CHEMBL1796276)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419770(CHEMBL1950035)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419761(CHEMBL1949919)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419759(CHEMBL1949916)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419754(CHEMBL1949910)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419769(CHEMBL1950034)
Affinity DataKi:  1nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50044686(CHEMBL3354594)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127610((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127610((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Affinity DataKi:  1.30nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50523557(CHEMBL4583231)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50044742(CHEMBL3354579)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50044677(CHEBI:59204 | Carbetocin)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50419758(CHEMBL1949914)
Affinity DataKi:  2nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419773(CHEMBL1949917)
Affinity DataKi:  2nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50347076(CHEMBL1796761)
Affinity DataKi:  2nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50044777(Arginine Vasopressin | Beta-Hypophamine | CHEBI:34...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419760(CHEMBL1949918)
Affinity DataKi:  2nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M5 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127604(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Affinity DataKi:  2.5nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M2 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419771(CHEMBL1950036)
Affinity DataKi:  3nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
Tohoku University And Department Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50523554(CHEMBL4467042)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]OT from recombinant human OTR expressed in HEK293 cell membranes measured after 1 hrMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50363991(CHEMBL1796763)
Affinity DataKi:  3nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419762(CHEMBL1949920)
Affinity DataKi:  3nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  3.10nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194208((1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]N-alpha-methyl-histamine from human histamine H3 receptor expressed in human HEK293-EBNA cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194208((1S,2R)-trans-2-[2-(4-chlorobenzylamino)ethyl]-1-(...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]Nalpha-methylhistamine form human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50165008((+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl...)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M3 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419764(CHEMBL1949922)
Affinity DataKi:  4nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419765(CHEMBL1949923)
Affinity DataKi:  4nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419766(CHEMBL1949924)
Affinity DataKi:  4nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127605((1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Affinity DataKi:  4.30nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M1 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50127608(2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | ...)
Affinity DataKi:  4.80nMAssay Description:Affinity against rat Histamine H3 receptor using [3H]-N-alpha-methyl histamineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419772(CHEMBL1950037)
Affinity DataKi:  5nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50419757(CHEMBL1949913)
Affinity DataKi:  5nMAssay Description:Apparent binding affinity to PI3Kalpha using PIP3 as substrate after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  5.09nMAssay Description:Displacement of [3H]YM-09151-2 from human dopamine D2S receptor in membrane suspensions by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H3 receptor(Homo sapiens (Human))
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50194202((1S,2R)-trans-2-[2-(cyclohexylmethylamino)ethyl]-1...)
Affinity DataKi:  5.30nMAssay Description:Displacement of [3H]Nalpha-methylhistamine form human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(RAT)
University Of Shizuoka

Curated by ChEMBL
LigandPNGBDBM50374004(CHEMBL271108)
Affinity DataKi:  6.30nMAssay Description:Displacement of [3H]NMS from muscarinic receptor M4 in Sprague-Dawley rat brain homogenates after 60 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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