TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human HGK using MBP as substrate assessed as residual activity by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.350nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.940nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Reversible inhibition of recombinant full-length N-terminal 6-His-tagged human BTK expressed in baculovirus infected Sf21 insect cells using fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of BTK (unknown origin) incubated 30 mins by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CYP2C9 using a fluorescent probe 7-methoxy-4-trifluoromethylcoumarinMore data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of PIM3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of recombinant LFA1/ICAM1-IG interaction (unknown origin) by time-resolved fluorimetry methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
TargetMitogen-activated protein kinase kinase kinase kinase 3(Homo sapiens (Human))
Biogen
Curated by ChEMBL
Biogen
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of GLK (unknown origin) by alphascreen assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Biogen Idec
Curated by ChEMBL
Biogen Idec
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK1/Cyclin B assessed as phosphorylation of Z-lyte Peptide at 0.017 to 30 nM by FRET assayMore data for this Ligand-Target Pair