Found 44 with Last Name = 'simmen' and Initial = 'k' 
Affinity DataKi: 0.0500nM ΔG°: -59.8kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.0500nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nM ΔG°: -58.0kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nM ΔG°: -58.0kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nM ΔG°: -58.0kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.200nM ΔG°: -56.3kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.25nM ΔG°: -55.7kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.300nM ΔG°: -55.3kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -54.0kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKi: 2.40nM ΔG°: -50.0kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 5nM ΔG°: -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 9.40nM ΔG°: -46.6kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 9.40nMAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 40nM ΔG°: -42.9kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 43nM ΔG°: -42.8kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Janssen Infectious Diseases - Diagnostics
Curated by ChEMBL
Janssen Infectious Diseases - Diagnostics
Curated by ChEMBL
Affinity DataKi: 130nMAssay Description:Inhibition of HCV RNA polymeraseMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nM ΔG°: -34.8kJ/molepH: 7.5 T: 2°CAssay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nM ΔG°: -34.8kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataKi: 1.07E+3nM ΔG°: -34.6kJ/molepH: 7.5 T: 2°CAssay Description:The aim of this in vitro assay was to measure the inhibition of HCV NS3/4A protease complexes by the compounds of the present invention. This assay p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TGFBR1More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
Affinity DataIC50: 123nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human cathepsin S in human JY cells assessed as p10 accumulation by fluorescence-based assayMore data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Janssen Infectious Diseases - Diagnostics
Curated by ChEMBL
Janssen Infectious Diseases - Diagnostics
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HCV RNA polymeraseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase gammaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+7nMAssay Description:Inhibition of peripheral benzodiazepine BZD receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+7nMAssay Description:Inhibition of peripheral benzodiazepine BZD receptor by radioligand binding assayMore data for this Ligand-Target Pair
