BindingDB PrimarySearch_ki

Found 1855 with Last Name = 'singh' and Initial = 'k'

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527524(CHEMBL4566742)

Ki: 0.0617nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527552(CHEMBL4435111)

Ki: 0.120nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527532(CHEMBL4441748)

Ki: 0.123nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527537(CHEMBL4453005)

Ki: 0.155nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527531(CHEMBL4524402)

Ki: 0.155nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527528(CHEMBL4441871)

Ki: 0.162nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527550(CHEMBL4461456)

Ki: 0.170nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527535(CHEMBL4589927)

Ki: 0.224nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527533(CHEMBL4592553)

Ki: 0.234nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527555(CHEMBL4530777)

Ki: 0.302nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527560(CHEMBL4444578)

Ki: 0.316nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527567(CHEMBL4473426)

Ki: 0.316nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527554(CHEMBL4460623)

Ki: 0.355nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527559(CHEMBL4591859)

Ki: 0.389nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL

PNG

BDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)

Ki: 0.398nMAssay Description:Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527525(CHEMBL4522249)

Ki: 0.513nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527529(CHEMBL4454600)

Ki: 0.562nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL

PNG

BDBM50427452(CHEMBL2326941)

Ki: 0.631nMAssay Description:Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair

PDB Reactome pathway
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3D Structure (crystal)

cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527527(CHEMBL4466777)

Ki: 0.661nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527530(CHEMBL4461705)

Ki: 0.676nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527534(CHEMBL4472307)

Ki: 0.676nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527548(CHEMBL4465097)

Ki: 0.851nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527549(CHEMBL4452707)

Ki: 0.871nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527523(CHEMBL4461658)

Ki: 1.20nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50402408(CHEMBL2203332)

Ki: 1.40nMAssay Description:Binding affinity to amyloid beta (1 to 40) (unknown origin) aggregatesMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527557(CHEMBL4533993)

Ki: 1.60nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Folylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL

PNG

BDBM50018235(5-Amino-2-{4-[(2,4-diamino-5-chloro-quinazolin-6-y...)

Ki: 1.70nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair

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Chymase(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50139758((2-Naphthalen-2-yl-1-naphthalen-1-yl-2-oxo-ethyl)-...)

Ki: 2.30nMAssay Description:Inhibition of chymase in human mast cells using Suc-Ala-Ala-Pro-Phe-(p-nitroanilide) as substrate for 15 mins by spectrophotometric methodMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527566(CHEMBL4472329)

Ki: 2.5nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527551(CHEMBL4575003)

Ki: 2.5nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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cAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
University Of Antwerp

Curated by ChEMBL

PNG

BDBM50527536(CHEMBL4466905)

Ki: 2.60nMAssay Description:Inhibition of human PDE4D2 expressed in Escherichia coli BL21 (DE3) using cAMP as substrate by PDELight HTS cAMP phosphodiesterase Kit basedMore data for this Ligand-Target Pair

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Estrogen receptor(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50254908(4-[1-(4-hydroxyphenyl)-4-methyl-5-{4-[2-(piperidin...)

Ki: 2.70nMAssay Description:Inhibition of ERalpha in human MCF7 cellsMore data for this Ligand-Target Pair

PDB Reactome pathway
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Phosphodiesterase(Trypanosoma brucei)
Vrije Universiteit Amsterdam

Curated by ChEMBL

PNG

BDBM50427452(CHEMBL2326941)

Ki: 4nMAssay Description:Inhibition of full length Trypanosoma brucei PDEB1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assayMore data for this Ligand-Target Pair

PDB
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3D Structure (crystal)

Histone deacetylase 6(Homo sapiens (Human))
University Of Toronto Mississauga

Curated by ChEMBL

PNG

BDBM50603512(CHEMBL5177475)

Ki: 4.10nMAssay Description:Binding affinity to full length human recombinant HDAC6 expressed in Sf9 baculovirus system assessed as inhibition constantMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Amyloid-beta precursor protein(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50488953(CHEMBL2296467)

Ki: 4.40nMAssay Description:Binding affinity to amyloid beta (1 to 40) (unknown origin) fibrilsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Histamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL

PNG

BDBM50524365(CHEMBL4579211)

Ki: 4.5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Histamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL

PNG

BDBM50524365(CHEMBL4579211)

Ki: 4.5nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Sodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL

PNG

BDBM50591808(CHEMBL5207397)

Ki: 4.70nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Histamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL

PNG

BDBM50524374(CHEMBL4453810)

Ki: 6.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair

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Histamine H3 receptor(Homo sapiens (Human))
Academy Of Scientific And Innovative Research (Acsir)

Curated by ChEMBL

PNG

BDBM50524374(CHEMBL4453810)

Ki: 6.10nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from recombinant human H3 receptor expressed in HEK293T cells measured after 90 mins by liquid scintillat...More data for this Ligand-Target Pair

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Amyloid-beta precursor protein(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50528756(CHEMBL4470128)

Ki: 6.90nMAssay Description:Displacement of [125I]IMPY from human amyloid beta(1-42) aggregates incubated for 3 hrs by gamma counting analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Acetylcholinesterase(Electrophorus electricus (Electric eel))
Banaras Hindu University

Curated by ChEMBL

PNG

BDBM50458333(CHEMBL4210820)

Ki: 7nMAssay Description:Non-competitive inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition b...More data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

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Matrix metalloproteinase-9(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)

Ki: 8nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Folylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL

PNG

BDBM50002472(5-Amino-2-{4-[(2-amino-5-chloro-4-oxo-3,4-dihydro-...)

Ki: 8.30nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair

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Folylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL

PNG

BDBM50002472(5-Amino-2-{4-[(2-amino-5-chloro-4-oxo-3,4-dihydro-...)

Ki: 8.30nMAssay Description:The apparent Km of compound as a substrate for partially purified mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair

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Folylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL

PNG

BDBM50003467(5-Amino-2-{4-[(2-amino-4-oxo-5-trifluoromethyl-3,4...)

Ki: 8.80nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair

Reactome pathway KEGG
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Sodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL

PNG

BDBM50591807(CHEMBL5178760)

Ki: 8.90nMAssay Description:Binding affinity to mouse GAT-1 assessed as inhibition constantMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Folylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
Medical University Of South Carolina

Curated by ChEMBL

PNG

BDBM50003471(5-Amino-2-{4-[(2-amino-4-oxo-5-trifluoromethyl-3,4...)

Ki: 11nMAssay Description:Inhibitory activity of the compound against hog liver Folyl polyglutamate synthetase (FPGS)More data for this Ligand-Target Pair

Reactome pathway KEGG
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Amyloid-beta precursor protein(Homo sapiens (Human))
Indian Institute Of Technology (Bhu)

Curated by ChEMBL

PNG

BDBM50598566(CHEMBL5192359)

Ki: 14nMAssay Description:Displacement of [125I]IMPY from amyloid beta (1 to 42) (unknown origin) measured by competitive radioligand binding assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
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Sodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Isf College Of Pharmacy

Curated by ChEMBL

PNG

BDBM50591806(CHEMBL5205864)

Ki: 14nMAssay Description:Inhibition of [3H]-GABA uptake at GAT-1 in rat forebrain synaptosomes assessed as inhibition constant preincubated for 8 mins followed by [3H]-GABA a...More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
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Displayed 1 to 50 (of 1855 total ) | Next | Last >>

Filter my 1855 hits

Targets 116▿
- Phosphodiesterase 127
- Histamine H3 receptor 116
- Acetylcholinesterase 115
- Cholinesterase 102
- Amyloid-beta precursor protein 85
- Proteasome subunit beta type-8 75
- Proteasome subunit beta type-5 75
- Androgen receptor 63
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B 57
- Vitamin D3 receptor 52
- Nuclear receptor ROR-gamma 45
- Histamine H2 receptor 44
- Prostaglandin G/H synthase 2 40
- 72 kDa type IV collagenase 38
- Prostaglandin G/H synthase 1 37
- Dipeptidyl peptidase 4 33
- Aromatase 32
- Insulin-like growth factor 1 receptor 30
- cAMP-specific 3',5'-cyclic phosphodiesterase 4D 30
- Steryl-sulfatase 29
- Receptor-type tyrosine-protein phosphatase beta 28
- Histone deacetylase 8 28
- Histone deacetylase 6 26
- Cytochrome P450 11B2, mitochondrial 26
- Presenilin-1 24
- Histone deacetylase 3 24
- Histone deacetylase 11 24
- Epidermal growth factor receptor 23
- Protease 21
- Fucose-binding lectin PA-IIL 21
- DNA gyrase subunit A/B 19
- PA-I galactophilic lectin 19
- Folylpolyglutamate synthase, mitochondrial 17
- Estrogen receptor 15
- Botulinum neurotoxin type A 15
- Amino acid transporter 14
- Proto-oncogene tyrosine-protein kinase receptor Ret 14
- Collagenase 3 13
- Sodium- and chloride-dependent GABA transporter 1 12
- DNA gyrase subunit B 11
- Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha 11
- Hepatocyte growth factor receptor 11
- ATP synthase subunit b-delta 11
- Matrix metalloproteinase-9 8
- Fibroblast growth factor 14 8
- Leucine-rich repeat serine/threonine-protein kinase 2 8
- Sodium channel protein type 8 subunit alpha 8
- Cholecystokinin receptor type A 8
- Poly [ADP-ribose] polymerase 1 7
- Receptor-type tyrosine-protein phosphatase F 6
- Amine oxidase [flavin-containing] A 6
- Stromelysin-1 6
- NAD-dependent protein deacylase sirtuin-5, mitochondrial 5
- Amine oxidase [flavin-containing] B 5
- Tyrosine-protein phosphatase non-receptor type 1 5
- Interstitial collagenase 5
- Trypsin 4
- Tyrosine-protein phosphatase non-receptor type 2 4
- Receptor tyrosine-protein kinase erbB-2 4
- Type 1 fimbrin D-mannose specific adhesin 3
- Low molecular weight phosphotyrosine protein phosphatase 3
- Receptor-type tyrosine-protein phosphatase mu 3
- Histone deacetylase 4 3
- Histone deacetylase 2 3
- NAD-dependent protein deacetylase sirtuin-3, mitochondrial 3
- Histone deacetylase 1 3
- Histone-lysine N-methyltransferase EZH2 3
- Receptor-type tyrosine-protein phosphatase C 3
- Receptor-type tyrosine-protein phosphatase epsilon 3
- Plasmepsin IV [1-448] 3
- Sortase family protein 3
- Receptor-type tyrosine-protein phosphatase gamma 3
- 5-hydroxytryptamine receptor 2C 3
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 3
- Histone-lysine N-methyltransferase EHMT2 3
- 5-hydroxytryptamine receptor 2B 3
- Sodium- and chloride-dependent betaine transporter 3
- 5-hydroxytryptamine receptor 2A 3
- Polyamine deacetylase HDAC10 2
- Gag-Pol polyprotein [K103N] 2
- Histone deacetylase 9 2
- Beta-secretase 1 2
- Histone deacetylase 7 2
- Histone deacetylase 5 2
- DNA topoisomerase 4 subunit A/B 2
- Sodium- and chloride-dependent GABA transporter 3 2
- Potassium voltage-gated channel subfamily H member 2 2
- Glycogen synthase kinase-3 beta 2
- Reverse transcriptase protein 2
- Protein arginine N-methyltransferase 5 1
- Cytochrome P450 11B1, mitochondrial 1
- Thyroid hormone receptor beta 1
- Plasmepsin II 1
- Histone-arginine methyltransferase CARM1 1
- Type-1/Type-2 angiotensin II receptor 1
- Sodium- and chloride-dependent GABA transporter 2 1
- Histone-lysine N-methyltransferase SETD7 1
- ATP synthase epsilon chain/gamma chain/subunit a/subunit alpha/subunit b/subunit b-delta/subunit beta/subunit c 1
- Thyroid hormone receptor alpha 1
- Matrix metalloproteinase-14 1
- Macrophage metalloelastase 1
- Nitric oxide synthase, inducible 1
- Insulin receptor 1
- Lectin A 1
- Cathepsin G 1
- Albumin 1
- Histone-lysine N-methyltransferase, H3 lysine-79 specific 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Receptor-type tyrosine-protein phosphatase alpha 1
- Chymase 1
- Trifunctional purine biosynthetic protein adenosine-3 1
- Glutamate receptor ionotropic, NMDA 1/2A 1
- Estrogen receptor beta 1
- Sortase 1
- N-lysine methyltransferase SMYD2 1
- N-lysine methyltransferase KMT5A 1
- ...
Publications 50▿
- J Med Chem 62: 4638-4655 (2019) 120
- J Med Chem 63: 13103-13123 (2020) 96
- J Med Chem 65: 8550-8595 (2022) 84
- J Med Chem 65: 3193-3217 (2022) 82
- Eur J Med Chem 150: 87-101 (2018) 76
- J Med Chem 63: 3485-3507 (2020) 74
- Eur J Med Chem 182: (2019) 73
- Eur J Med Chem 177: 116-143 (2019) 72
- J Med Chem 56: 1136-48 (2013) 63
- Bioorg Med Chem Lett 16: 4252-6 (2006) 59
- Bioorg Med Chem 27: 4013-4029 (2019) 54
- J Med Chem 62: 6137-6145 (2019) 54
- ACS Med Chem Lett 5: 199-204 (2014) 54
- Eur J Med Chem 215: (2021) 52
- J Med Chem 61: 3870-3888 (2018) 52
- J Med Chem 65: 8525-8549 (2022) 48
- Eur J Med Chem 60: 89-100 (2013) 46
- Eur J Med Chem 152: 148-159 (2018) 44
- Bioorg Med Chem Lett 14: 499-504 (2003) 44
- Bioorg Med Chem 46: (2021) 37
- Bioorg Med Chem 27: 3998-4012 (2019) 34
- Bioorg Med Chem Lett 29: 1565-1571 (2019) 33
- Bioorg Med Chem Lett 24: 1918-22 (2014) 33
- J Med Chem 62: 2651-2665 (2019) 32
- Eur J Med Chem 92: 246-56 (2015) 31
- Bioorg Med Chem Lett 14: 1683-8 (2004) 31
- Bioorg Med Chem Lett 36: (2021) 30
- J Med Chem 58: 9382-94 (2015) 30
- Eur J Med Chem 148: 436-452 (2018) 24
- ACS Med Chem Lett 7: 702-7 (2016) 21
- Eur J Med Chem 151: 62-97 (2018) 19
- Eur J Med Chem 234: (2022) 18
- J Med Chem 65: 6903-6925 (2022) 17
- J Med Chem 63: 11522-11547 (2020) 16
- Bioorg Med Chem Lett 23: 6598-603 (2013) 15
- ACS Med Chem Lett 11: 528-534 (2020) 15
- J Med Chem 60: 338-348 (2017) 15
- US Patent US8629135 (2014) 14
- Bioorg Med Chem Lett 27: 398-402 (2017) 14
- Eur J Med Chem 166: 351-368 (2019) 12
- Eur J Med Chem 182: (2019) 12
- Eur J Med Chem 161: 252-276 (2019) 11
- Eur J Med Chem 164: 499-516 (2019) 9
- Eur J Med Chem 74: 491-501 (2014) 9
- Bioorg Med Chem Lett 25: 2713-9 (2015) 8
- J Med Chem 65: 14015-14031 (2022) 8
- J Med Chem 32: 1559-65 (1989) 7
- Eur J Med Chem 182: (2019) 7
- J Med Chem 35: 4078-85 (1992) 7
- Bioorg Med Chem Lett 17: 2749-55 (2007) 6
Institutions 35▿
- Indian Institute Of Technology (Bhu) 213
- Indian Institute Of Technology (Banaras Hindu University) 162
- Weill Cornell Medicine 150
- Vrije Universiteit Amsterdam 140
- Academy Of Scientific And Innovative Research (Acsir) 120
- University Of Toronto Mississauga 114
- Banaras Hindu University 100
- Discovery Research-Dr. Reddy'S Laboratories 75
- University Of Antwerp 74
- Punjabi University 64
- University Of British Columbia 63
- Procter & Gamble Pharmaceuticals 59
- University Of Wisconsin-Milwaukee 54
- Indian Institute Of Technology Bombay 48
- Teijin Pharma 45
- Csir-Central Drug Research Institute 44
- M.S. University Of Baroda 33
- Piramal Enterprises 31
- Novartis Institutes For Biomedical Research 30
- Merck Research Laboratories 21
- Isf College Of Pharmacy 18
- University Of Cape Town 17
- TBA 16
- Biota Holdings 15
- The Scripps Research Institute 15
- Medical University Of South Carolina 14
- Queen'S University At Kingston 14
- Binghamton University 14
- Kurukshetra University 12
- Csir-Central Drug Research Institute (Csir-Cdri) 9
- Universidad Complutense De Madrid 9
- University Of Bayreuth 8
- Acelot 8
- Suez Canal University 7
- Lucknow University 6
Affinity: 0.0040 to 3.0E+6 nM▿
- Ki 294
- IC50 1337
- Kd 125
- EC50 99
- Affinity ≤ nM
Xtal structures: 53
Docked structures: 5
Catalog Cmpds: 160