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Found 592 with Last Name = 'skaltsounis' and Initial = 'l'
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50: <0.5nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydro...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50:  0.870nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252978((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-pyrrolidin-1-y...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  2.90nMAssay Description:Displacement of fluorescent estrogen ES2 from human recombinant ERbeta by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  3.20nMAssay Description:Displacement of fluorescent estrogen ES2 from human recombinant ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50259591(CHEMBL493656)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50259591(CHEMBL493656)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7425((2 Z,3 E)-5,6-Dichloroindirubin-3 -acetoxime | 6,5...)
Affinity DataIC50:  4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7424((2 Z,3 E)-5,6-Dichloroindirubin-3 -oxime | 5,6-dic...)
Affinity DataIC50:  4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252978((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-pyrrolidin-1-y...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of recombinant c-Src (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Sus scrofa)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM7401((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of porcine brain GSK3beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrateMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7401((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Affinity DataIC50:  5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7428((2 Z,3 E)-6-Bromo-5-nitroindirubin-3 -acetoxime | ...)
Affinity DataIC50:  6nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7421((2 Z,3 E)-6-Bromo-5-methylindirubin-3 -oxime | 6-b...)
Affinity DataIC50:  6nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7427((2 Z,3 E)-6-Bromo-5-nitroindirubin-3 -oxime | 6-Br...)
Affinity DataIC50:  7nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7422((2 Z,3 E)-6-Bromo-5-methylindirubin-3 -acetoxime |...)
Affinity DataIC50:  7nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50:  7.10nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252729((2''Z-3''E)-6-Bromoindirubin-3''-(O-{2-[4-(2-hydro...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of recombinant JAK2 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7402((2 Z,3 E)-6-Bromoindirubin-3 -acetoxime | 6-bromoi...)
Affinity DataIC50:  10nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7410((2 Z,3 E)-6-Iodoindirubin-3 -oxime | 3-[(2Z,3E)-3-...)
Affinity DataIC50:  10nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7411((2 Z,3 E)-6-Iodoindirubin-3 -acetoxime | 6-iodoind...)
Affinity DataIC50:  13nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydro...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7408((2 Z,3 E)-6-Chloroindirubin-3 -acetoxime | 6-chlor...)
Affinity DataIC50:  17nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7407((2 Z,3 E)-6-Chloroindirubin-3 -oxime | 6-chloro-3-...)
Affinity DataIC50:  20nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7393(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50:  22nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7420((2 Z)-6-Bromo-5-methylindirubin | 6-bromo-5-methyl...)
Affinity DataIC50:  25nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM50191431(5-bromoindirubin-3'-oxime | CHEMBL379494)
Affinity DataIC50:  28nMAssay Description:Inhibition of mammalian CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7423((2 Z)-5,6-Dichloroindirubin | 5,6-dichloro-3-[(2Z)...)
Affinity DataIC50:  30nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7403((2 Z,3 E)-6-Bromoindirubin-3 -methoxime | 6-bromo-...)
Affinity DataIC50:  30nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydro...)
Affinity DataIC50:  34nMAssay Description:Inhibitory constant against Serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252767((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-{4-[2-(2-hydro...)
Affinity DataIC50:  34.1nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  41.5nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252727((2'Z-3'E)-6-Bromoindirubin-3'-(O-{2-[N-methyl,N-(2...)
Affinity DataIC50:  42nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50250229(2-(2,4-dihydroxyphenyl)-3-formyl-4-hydroxy-6-metho...)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]estradiol from estrogen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7400(6-bromo-3-[(2Z)-3-oxo-2,3-dihydro-1H-indol-2-ylide...)
Affinity DataIC50:  45nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50250228(2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzof...)
Affinity DataIC50:  46nMAssay Description:Displacement of [3H]estradiol from estrogen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7409((2 Z)-6-Iodoindirubin | 6-iodo-3-[(2Z)-3-oxo-2,3-d...)
Affinity DataIC50:  55nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
University of Athens

LigandPNGBDBM7424((2 Z,3 E)-5,6-Dichloroindirubin-3 -oxime | 5,6-dic...)
Affinity DataIC50:  60nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7413((2 Z,3 E)-6-Vinylindirubin-3 -oxime | 6-ethenyl-3-...)
Affinity DataIC50:  60nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Porcine)
University of Athens

LigandPNGBDBM7414((2 Z,3 E)-6-Vinylindirubin-3 -acetoxime | 6-vinyli...)
Affinity DataIC50:  65nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252978((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-pyrrolidin-1-y...)
Affinity DataIC50:  67nMAssay Description:Inhibition of recombinant ABL1 (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Sus scrofa)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50426336(CHEMBL2321952)
Affinity DataIC50:  70nMAssay Description:Inhibition of porcine brain GSK3beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Beckman Research Institute

Curated by ChEMBL
LigandPNGBDBM50252978((2'Z-3'E)-6-Bromoindirubin-3'-[O-(2-pyrrolidin-1-y...)
Affinity DataIC50:  79nMAssay Description:Inhibition of recombinant Aurora A (unknown origin) after 120 mins in presence of [33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM7401((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Affinity DataIC50:  83nMAssay Description:Inhibition of CDK5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Cnrs

Curated by ChEMBL
LigandPNGBDBM7401((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Affinity DataIC50:  83nMAssay Description:Inhibition of mammalian CDK5/p25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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