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Found 219 with Last Name = 'skell' and Initial = 'j'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50474902(CHEMBL187309)
Affinity DataKi:  0.340nMAssay Description:Inhibition of [3H]- cytisine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cortical membranesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018174(CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hyd...)
Affinity DataKi:  500nMpH: 5.0Assay Description:Inhibition of chymotrypsin-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018174(CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hyd...)
Affinity DataKi:  700nMpH: 5.0Assay Description:Inhibition of papain-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018173(CHEMBL22745 | N-{2-[(2-Acetylamino-propionyl)-hydr...)
Affinity DataKi:  2.50E+4nMpH: 5.5Assay Description:Inhibition of papain-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018174(CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hyd...)
Affinity DataKi:  2.60E+4nMpH: 7.8Assay Description:Inhibition of chymotrypsin-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018173(CHEMBL22745 | N-{2-[(2-Acetylamino-propionyl)-hydr...)
Affinity DataKi:  3.00E+4nMpH: 7.0Assay Description:Inhibition of papain-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018174(CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hyd...)
Affinity DataKi:  3.10E+4nMpH: 7.0Assay Description:Initial rate of reaction between Chymotrypsinogen and BzArg p-nitro-anilide in the presence of 400 microM of the compound at pH 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPapain(Carica papaya)
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018173(CHEMBL22745 | N-{2-[(2-Acetylamino-propionyl)-hydr...)
Affinity DataKi:  3.80E+4nMpH: 5.0Assay Description:Inhibition of papain-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018175(CHEMBL22389 | N-{1-Benzyl-2-[(pyridine-3-carbonyl)...)
Affinity DataKi:  4.80E+4nMpH: 5.0Assay Description:Inhibition of chymotrypsin-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018175(CHEMBL22389 | N-{1-Benzyl-2-[(pyridine-3-carbonyl)...)
Affinity DataKi:  4.80E+4nMpH: 5.0Assay Description:Inhibition of chymotrypsin-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 7.8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018174(CHEMBL283109 | N-{2-[(2-Acetylamino-propionyl)-hyd...)
Affinity DataKi:  4.80E+4nMpH: 5.0Assay Description:Inhibition of papain-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Amherst College

Curated by ChEMBL
LigandPNGBDBM50018173(CHEMBL22745 | N-{2-[(2-Acetylamino-propionyl)-hydr...)
Affinity DataKi: >8.00E+6nMpH: 5.0Assay Description:Inhibition of chymotrypsin-catalyzed hydrolysis of BzArg p-nitroanilide by compound at pH 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14776(2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120086(8-Cyclohexylamino-1,3-diethyl-7-(3-fluoro-4-methox...)
Affinity DataIC50:  0.300nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120069(8-Cyclohexylamino-1,3-diethyl-7-(3-fluoro-4-hydrox...)
Affinity DataIC50:  0.330nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120079(7-(3-Chloro-4-methoxy-benzyl)-8-cyclohexylamino-1,...)
Affinity DataIC50:  0.580nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120074(8-Cyclohexylamino-1,3-diethyl-7-(4-hydroxy-benzyl)...)
Affinity DataIC50:  0.600nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120067(8-Cyclopentylamino-1,3-diethyl-7-(3-fluoro-4-metho...)
Affinity DataIC50:  0.690nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120072(8-Cyclopentylamino-1,3-diethyl-7-(3-fluoro-4-hydro...)
Affinity DataIC50:  0.820nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120071(7-(3-Chloro-4-methoxy-benzyl)-8-cyclopentylamino-1...)
Affinity DataIC50:  1.10nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120080(8-Cyclohexylamino-1,3-diethyl-7-(3-hydroxy-benzyl)...)
Affinity DataIC50:  1.20nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120070(8-Cyclopentylamino-1,3-diethyl-7-(4-methoxy-benzyl...)
Affinity DataIC50:  1.5nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120081(7-(3-Bromo-4-methoxy-benzyl)-8-cyclohexylamino-1,3...)
Affinity DataIC50:  1.70nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120078(7-(3-Chloro-4-hydroxy-benzyl)-8-cyclopentylamino-1...)
Affinity DataIC50:  1.80nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120085(7-(3-Chloro-4-hydroxy-benzyl)-8-cyclohexylamino-1,...)
Affinity DataIC50:  2nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273951(CHEMBL4126165)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273914(CHEMBL4126686)
Affinity DataIC50:  2nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120068(8-Cyclopentylamino-1,3-diethyl-7-(4-methoxy-benzyl...)
Affinity DataIC50:  2.10nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165781((R)-7-Benzyl-2-chloro-5-ethyl-3-(4-hydroxy-benzyl)...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165771((R)-7-Benzyl-2-bromo-5-ethyl-3-(4-hydroxy-benzyl)-...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120083(8-Cyclohexylamino-1,3-diethyl-7-(4-methoxy-benzyl)...)
Affinity DataIC50:  2.60nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273903(CHEMBL4129717)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273915(CHEMBL4127891)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273913(CHEMBL4127663)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273916(CHEMBL4126289)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165773((R)-7-Benzyl-5-ethyl-3-(4-hydroxy-benzyl)-2-iodo-7...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataIC50:  3.5nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120075(7-Benzo[1,3]dioxol-5-ylmethyl-8-cyclohexylamino-1,...)
Affinity DataIC50:  3.70nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273950(CHEMBL4128240)
Affinity DataIC50:  4nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM14777((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50120076(8-Cyclohexylamino-1,3-diethyl-7-(4-hydroxy-3-methy...)
Affinity DataIC50:  4.5nMAssay Description:Concentration required to inhibit phosphodiesterase type 5 (PDE5) isolated from corpus cavernosum by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50140595((R)-2,7-Dibenzyl-5-ethyl-7,8-dihydro-1H,5H-imidazo...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273965(CHEMBL4127923)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273948(CHEMBL4127873)
Affinity DataIC50:  5nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Bristol-Myers

Curated by ChEMBL
LigandPNGBDBM50241107(1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazo...)
Affinity DataIC50:  5.20nMAssay Description:In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165787((R)-7-Benzyl-5-ethyl-3-(4-hydroxy-benzyl)-2-phenyl...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273902(CHEMBL4126659)
Affinity DataIC50:  6nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50273963(CHEMBL4128890)
Affinity DataIC50:  6nMAssay Description:Inhibition of HIV1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50165782(5-Ethyl-1-(4-hydroxy-benzyl)-2-phenylethynyl-7-((R...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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