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Found 603 with Last Name = 'skene' and Initial = 'rj'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394247(CHEMBL2159192)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394245(CHEMBL2159190)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335797(2-[2-(3-(R)-Aminopyrimidin-1-yl)-5-bromo-6-oxo-6H-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16281(2-({2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-meth...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335784(2-[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16274(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxo-...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335792(2-{6-[3(R)-Aminopiperidin-1-yl]-2,4-dioxo-3,4-dihy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335768(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-methoxy-6-oxo-6...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394248(CHEMBL2159193)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394243(CHEMBL2159188)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317946(CHEMBL1095451 | N-hydroxy-3-(3-(5-methyl-1-pheneth...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317947((R)-N-hydroxy-3-(3-(5-methyl-1-(1-methylpiperidin-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317949((R)-N-hydroxy-3-(3-(1-(1-isopropylpiperidin-3-yl)-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317960(3-(3-(5-benzyl-4-methyl-1-phenethyl-1H-imidazol-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16273(2-({2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxo-...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335774(2-((2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-6-oxopyr...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16279(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxo-3...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335756(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-prop-1-ynyl-6-o...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335757(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-ethynyl-6-oxo-6...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335759(2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-(1H-pyrro...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16275(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxo-...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335777(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-fluoro-6-oxo-6H...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335771(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-iodo-6-oxo-6H-p...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335793(2-((2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-6-oxopyr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335798(2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-((E)-2-py...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317954((R)-N-hydroxy-3-(3-(1-(1-isopropylpiperidin-3-yl)-...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317948(6-(1-((R)-1-ethylpiperidin-3-yl)-5-methyl-4-phenyl...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317957((R)-3-(3-(4-benzyl-5-methyl-1-(1-methylpiperidin-3...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394246(CHEMBL2159191)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335775(2-[2-(3-(R)-Aminopiperidin-1-yl)-5-chloro-6-oxo-6H...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394242(CHEMBL2159187)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317962(3-(3-(4,5-dimethyl-1-phenethyl-1H-imidazol-2-yl)ph...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317956(3-(3-(4-benzyl-5-methyl-1-phenethyl-1H-imidazol-2-...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317951(CHEMBL1096433 | N-hydroxy-3-(3-(4-methyl-1-pheneth...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317965(CHEMBL1099096 | N-hydroxy-3-(3-(1-phenethyl-1H-ben...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317953((R)-3-(3-(1-(1-ethylpiperidin-3-yl)-4-methyl-5-phe...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605601(CHEMBL5184138)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM16280(2-({2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxo...)
Affinity DataIC50:  8nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit DPP enzymes mediated cleavage of Ala-Pro-7-amido-4-trifluoromethylcoumarin in a fluorogenic assay....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335753(2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-vinyl-6H-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50375237(CHEMBL272114)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335787(6-[3-(R)-Aminopiperidin-1-yl]-1-(2-bromo-5-fluorob...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335794(2-((2-(3-(R)-Aminopiperidin-1-yl)-5-chloro-6-oxopy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335795(2-((2-(3-(R)-Aminopiperidin-1-yl)-5-fluoro-6-oxopy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50335773(2[2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-4-methyl-6...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605597(CHEMBL5204161)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605598(CHEMBL5188193)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50394249(CHEMBL2159194)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50317983(CHEMBL1099057 | N-hydroxy-3-(3-(1-(2-(piperidin-1-...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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