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Found 282 with Last Name = 'smith' and Initial = 'cp'
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM15517((3R, 4R)-1-(6-Phenylpyrimidin-4-yl)-4-(2, 4, 5-tri...)
Affinity DataKi:  6nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50379784(CHEMBL2011537)
Affinity DataKi:  6nMAssay Description:Antagonist activity at human MCH1R expressed in forskolin-stimulated CHO cells assessed as inhibition of MCH-induced cAMP accumulation after 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  0.690nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.00029-0.001More data for this Ligand-Target Pair
In DepthDetails Article
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50452855(Isoptpo Hyoscine | Scopolamine)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362677(CHEMBL1939618)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048608(CHEMBL154488 | Indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM10972((3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyr...)
Affinity DataIC50:  9nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362678(CHEMBL1939480)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362683(CHEMBL1939476)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362685(CHEMBL1939475)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50379784(CHEMBL2011537)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048589(CHEMBL152842 | Indol-1-yl-methyl-pyridin-4-yl-amin...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  27nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.01-0.069More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362675(CHEMBL1939620)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362676(CHEMBL1939621)
Affinity DataIC50:  29nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  31nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.023-0.041More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362667(CHEMBL1939631)
Affinity DataIC50:  37nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362680(CHEMBL1939478)
Affinity DataIC50:  38nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362672(CHEMBL1939622)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290392(Benzyl-carbamic acid 1-[(3-fluoro-pyridin-4-yl)-pr...)
Affinity DataIC50:  43nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362667(CHEMBL1939631)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362673(CHEMBL1939624)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290391(CHEMBL42531 | Methyl-carbamic acid 1-[(3-fluoro-py...)
Affinity DataIC50:  58nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362666(CHEMBL1939628)
Affinity DataIC50:  97nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362665(CHEMBL1939632)
Affinity DataIC50:  102nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362665(CHEMBL1939632)
Affinity DataIC50:  102nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362671(CHEMBL1939623)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50379789(CHEMBL2011534)
Affinity DataIC50:  110nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362669(CHEMBL1939625)
Affinity DataIC50:  115nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362670(CHEMBL1939627)
Affinity DataIC50:  117nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362666(CHEMBL1939628)
Affinity DataIC50:  125nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  130nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362687(CHEMBL1939474)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50379785(CHEMBL2011528)
Affinity DataIC50:  140nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against [3H]idazoxan binding to Alpha-2 adrenergic receptor in rat cortex, in the presence of GPPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362679(CHEMBL1939617)
Affinity DataIC50:  144nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362674(CHEMBL1939619)
Affinity DataIC50:  167nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290389(CHEMBL295462 | Methyl-carbamic acid 1-(3-fluoro-py...)
Affinity DataIC50:  190nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22More data for this Ligand-Target Pair
In DepthDetails Article
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362671(CHEMBL1939623)
Affinity DataIC50:  220nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362684(CHEMBL1939477)
Affinity DataIC50:  230nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against [3H]yohimbine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048600(CHEMBL154541 | Ethyl-indol-1-yl-pyridin-4-yl-amine)
Affinity DataIC50:  250nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against acetylcholinesterase in rat striatal preparationMore data for this Ligand-Target Pair
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  330nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50379790(CHEMBL2011535)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant DPP4 using H-Gly-Pro-7-amino-4-methylcoumarin as substrate assessed as inhibition of 7-amino-4-methylcoumarin formati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362682(CHEMBL1939473)
Affinity DataIC50:  350nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Prosidion

Curated by ChEMBL
LigandPNGBDBM50362668(CHEMBL1939626)
Affinity DataIC50:  373nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50048580(CHEMBL29835 | Indol-1-yl-propyl-pyridin-4-yl-amine...)
Affinity DataIC50:  430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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