Affinity DataKi: 6nMAssay Description:Antagonist activity at human MCH1R expressed in forskolin-stimulated CHO cells assessed as inhibition of MCH-induced cAMP accumulation after 90 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.690nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.00029-0.001More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the absence of ZnMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate (QNB) binding from rat forebrain membranes in the presence of ZnMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.01-0.069More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.023-0.041More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
Affinity DataIC50: 97nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 102nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Compound was evaluated in vitro in rats for the inhibition of brain (striatal) acetylcholinesterase (AChEI) using acetylthiocholine as substrate; 0.0...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at human MCH1R expressed in CHO cells assessed as inhibition of MCH-induced responseMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against [3H]idazoxan binding to Alpha-2 adrenergic receptor in rat cortex, in the presence of GPPMore data for this Ligand-Target Pair
Affinity DataIC50: 144nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 167nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Compound was evaluated in vitro for the inhibition of human serum Butyrylcholinesterase using butyrylthiocholine as substrate; 0.15-0.22More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against [3H]yohimbine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 250nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibitory activity against acetylcholinesterase in rat striatal preparationMore data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(RAT)
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibitory activity against [3H]clonidine binding to Alpha-2 adrenergic receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant DPP4 using H-Gly-Pro-7-amino-4-methylcoumarin as substrate assessed as inhibition of 7-amino-4-methylcoumarin formati...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
Affinity DataIC50: 373nMAssay Description:Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesisMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Hoechst-Roussel Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 430nMAssay Description:Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparationMore data for this Ligand-Target Pair