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Found 16 with Last Name = 'smith' and Initial = 'cw'
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13614(2-(carboxymethoxy)-5-[(2S)-2-(pentylcarbamoyl)-2-[...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nM ΔG°:  -37.3kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13609(2-{4-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13610(2-(carboxymethoxy)-5-[(2S)-2-(3-formamidopropanoic...)
Affinity DataKi:  2.80E+3nM ΔG°:  -31.4kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13613(2-{4-[(2S)-2-({[(1S)-1-carboxy-2-phenylethyl]carba...)
Affinity DataKi:  3.40E+3nM ΔG°:  -30.9kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nM ΔG°:  -30.0kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13608(2-{4-[(2S)-2-(3-formamidopropanoic acid)-2-(pentyl...)
Affinity DataKi:  1.20E+4nM ΔG°:  -27.8kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13607(3-{[(1S)-1-(pentylcarbamoyl)-2-[4-(sulfooxy)phenyl...)
Affinity DataKi:  3.00E+4nM ΔG°:  -25.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))
Pharmacia

LigandPNGBDBM13612(Compound VII | methyl 2-(2-methoxy-2-oxoethoxy)-5-...)
Affinity DataKi: >1.00E+5nM ΔG°: >-22.6kJ/molepH: 7.2 T: 2°CAssay Description:Hydrolysis of substrate p-nitrophenyl phosphate was monitored on a 96-well microplate reader. Concentrations of PTP1B inhibitors that resulted in 50%...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367718(CHEMBL3037868)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367714(CHEMBL1790111)
Affinity DataIC50:  49nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367716(CHEMBL1790120)
Affinity DataIC50:  2.50E+3nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367717(CHEMBL1790115)
Affinity DataIC50:  6.00E+3nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367713(CHEMBL1790122)
Affinity DataIC50:  6.20E+3nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50022938(CHEMBL438719 | H-Pro-His-Pro-Phe-His-Phe-Phe-Val-T...)
Affinity DataIC50:  1.00E+4nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Upjohn

Curated by ChEMBL
LigandPNGBDBM50367715(CHEMBL1790121)
Affinity DataIC50:  1.70E+5nMAssay Description:In vitro inhibitory activity against renin from lyophilized human plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed