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Found 66 with Last Name = 'smith' and Initial = 'mc'
TargetGlutamate racemase(Lactobacillus fermentum)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50118891((4S)-4-(2-NAPHTHYLMETHYL)-D-GLUTAMIC ACID | 2-Amin...)
Affinity DataKi:  16nMAssay Description:Binding affinity against Glutamate RacemaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182218(CHEMBL382875 | [methyl-(7-nitro-benzo[1,2,5]oxadia...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
LigandPNGBDBM50182213((7-dimethylamino-2-oxo-2H-chromen-4-yl)-acetic aci...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182215(CHEMBL205591 | [methyl-(7-nitro-benzo[1,2,5]oxadia...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182219((7-dimethylamino-2-oxo-2H-chromen-4-yl)-acetic aci...)
Affinity DataIC50:  10.1nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182214(CHEMBL381040 | [methyl-(7-nitro-benzo[1,2,5]oxadia...)
Affinity DataIC50:  225nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50182217((7-dimethylamino-2-oxo-2H-chromen-4-yl)-acetic aci...)
Affinity DataIC50:  695nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340226(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(oxazol...)
Affinity DataIC50:  970nMAssay Description:Inhibition of Adenosine receptor A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340223(4-amino-6-(4-methyloxazol-2-yl)-1-((6-methylpyridi...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of Adenosine receptor A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340221(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(2H-1,2...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Adenosine receptor A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340230(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(1H-pyr...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of Adenosine receptor A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340220(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(triflu...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340221(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(2H-1,2...)
Affinity DataEC50:  51nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340222(4-amino-1-((2-methylthiazol-4-yl)methyl)-6-(triflu...)
Affinity DataEC50:  79nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340223(4-amino-6-(4-methyloxazol-2-yl)-1-((6-methylpyridi...)
Affinity DataEC50:  87nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340224(4-amino-1-((5-methylpyridin-2-yl)methyl)-6-(triflu...)
Affinity DataEC50:  95nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340225(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-((tetra...)
Affinity DataEC50:  99nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340226(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(oxazol...)
Affinity DataEC50:  102nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340227(4-amino-1-((5-methylisoxazol-3-yl)methyl)-6-(trifl...)
Affinity DataEC50:  103nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340228(4-amino-1-((6-methylpyridazin-3-yl)methyl)-6-(trif...)
Affinity DataEC50:  411nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340229(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-((tetra...)
Affinity DataEC50:  474nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340230(4-amino-1-((6-methylpyridin-3-yl)methyl)-6-(1H-pyr...)
Affinity DataEC50:  633nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340231(4-amino-1-(3-methoxypropyl)-6-(trifluoromethyl)-1H...)
Affinity DataEC50:  833nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340232(4-amino-1-((tetrahydro-2H-pyran-3-yl)methyl)-6-(tr...)
Affinity DataEC50:  1.44E+3nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340233(4-amino-1-((2-methyloxazol-4-yl)methyl)-6-(trifluo...)
Affinity DataEC50:  193nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340234(4-amino-1-benzyl-6-(trifluoromethyl)-1H-imidazo[4,...)
Affinity DataEC50:  269nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340235(4-amino-1-((6-methylpyridin-2-yl)methyl)-6-(triflu...)
Affinity DataEC50:  328nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340236(4-amino-1-((5-methylpyrazin-2-yl)methyl)-6-(triflu...)
Affinity DataEC50:  352nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340237(4-amino-6-((1-methylpiperidin-4-yl)methoxy)-1-((6-...)
Affinity DataEC50: >4.00E+3nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340238(4-amino-6-(3-methoxypropoxy)-1-((6-methylpyridin-3...)
Affinity DataEC50: >4.00E+3nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50340239(4-amino-1-((2-methylpyrimidin-5-yl)methyl)-6-(trif...)
Affinity DataEC50:  366nMAssay Description:Agonist activity at Toll-like receptor 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354919(CHEMBL1836893)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354920(CHEMBL1836892)
Affinity DataEC50:  0.400nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354921(CHEMBL1836889)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354922(CHEMBL1836890)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354923(CHEMBL1836881)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354924(CHEMBL1836885)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354925(CHEMBL1837074)
Affinity DataEC50:  2.30nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354926(CHEMBL1836887)
Affinity DataEC50:  2.70nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354927(CHEMBL1836888)
Affinity DataEC50:  4.10nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354928(CHEMBL1836883)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354929(CHEMBL1836886)
Affinity DataEC50:  6.60nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354930(CHEMBL1836884)
Affinity DataEC50:  6.90nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354931(CHEMBL1836880)
Affinity DataEC50:  9nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354932(CHEMBL1836882)
Affinity DataEC50:  26.9nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354933(CHEMBL1837075)
Affinity DataEC50:  28.6nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354934(CHEMBL1836895)
Affinity DataEC50:  31nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354935(CHEMBL1836896)
Affinity DataEC50:  32.1nMAssay Description:Agonist activity at TLR7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetToll-like receptor 7(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50354936(CHEMBL1837072)
Affinity DataEC50:  45.8nMAssay Description:Agonist activity at TLR7 in human PBMC assessed as induction of type 1 interferon productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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