Found 29 with Last Name = 'smith' and Initial = 'wl' 
Affinity DataIC50: 7.90nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 85nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 350nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 590nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: <1.30E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a...More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+4nMpH: 8.0 T: 2°CAssay Description:For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [R120A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 750nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [S530A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 190nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [S530A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 240nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [R120A,Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 620nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 370nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 1.60E+3nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
Affinity DataKd: 160nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2(Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 130nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [R120Q](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 220nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
