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Found 120 with Last Name = 'smith-swintosky' and Initial = 'v'
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  3.30nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13057(CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...)
Affinity DataKi:  12nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13057(CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...)
Affinity DataKi:  12nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Affinity DataKi:  18nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50098106(CHEMBL24259 | PHENYLSULFAMATE | Sulfamic acid phen...)
Affinity DataKi:  36nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13057(CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...)
Affinity DataKi:  38nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13057(CHEMBL417656 | Compound 9 | Cyclic Sulfate Analogu...)
Affinity DataKi:  38nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376374(CHEMBL26303)
Affinity DataKi:  200nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  300nMAssay Description:Inhibition of human carbonic anhydrase 2 by ThermoFluor methodMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376372(CHEMBL26590)
Affinity DataKi:  350nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  430nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  430nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  450nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  500nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataKi:  500nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124157(4-nitrophenylsulfamide | CHEMBL168778 | N-(4-nitro...)
Affinity DataKi:  892nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50188393((2,2-dimethyl-1,3-dioxolan-4-yl)methyl sulfamate |...)
Affinity DataKi:  1.02E+3nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376368(CHEMBL26780)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376370(CHEMBL410329)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124157(4-nitrophenylsulfamide | CHEMBL168778 | N-(4-nitro...)
Affinity DataKi:  1.74E+3nMAssay Description:Inhibition of human CA2 by 4-nitrophenyl acetate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)
Affinity DataKi:  6.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124170(CHEMBL168514 | N-phenylsulfamide | PHENYLSULFAMIDE)
Affinity DataKi:  7.96E+3nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124170(CHEMBL168514 | N-phenylsulfamide | PHENYLSULFAMIDE)
Affinity DataKi:  8.02E+3nMAssay Description:Inhibition of human CA2 by 4-nitrophenyl acetate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124171(4-methoxyphenylsulfamide | CHEMBL165878 | N-(4-met...)
Affinity DataKi:  1.44E+4nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50124171(4-methoxyphenylsulfamide | CHEMBL165878 | N-(4-met...)
Affinity DataKi:  1.88E+4nMAssay Description:Inhibition of human CA2 by 4-nitrophenyl acetate hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163316(CHEMBL177425 | N-{[(3aR,5aS,8aS,8bS)-7,7-dimethyl-...)
Affinity DataKi:  2.00E+4nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163316(CHEMBL177425 | N-{[(3aR,5aS,8aS,8bS)-7,7-dimethyl-...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376375(CHEMBL412256)
Affinity DataKi:  3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376373(CHEMBL260866)
Affinity DataKi:  3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376371(CHEMBL264966)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50376369(CHEMBL410328)
Affinity DataKi: >3.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13055(CHEMBL283695 | Compound 8 | Topiramate Sulfamide A...)
Affinity DataKi:  3.40E+5nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in esterase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13055(CHEMBL283695 | Compound 8 | Topiramate Sulfamide A...)
Affinity DataKi:  3.40E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by 4-NPA hydrolysis assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50188392(CHEMBL378292 | N-(2,2-dimethyl-1,3-dioxolan-4-ylme...)
Affinity DataKi:  4.08E+5nMAssay Description:Inhibition of human CA2 by carbon dioxide hydrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM13055(CHEMBL283695 | Compound 8 | Topiramate Sulfamide A...)
Affinity DataKi:  6.50E+5nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163317((3,4-dihydro-2H-chromen-2-yl)methyl sulfamate | CH...)
Affinity DataIC50:  130nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163318(CHEMBL175786 | Sulfamic acid benzo[1,3]dioxol-2-yl...)
Affinity DataIC50:  280nMAssay Description:Inhibitory constant value for Carbonic anhydrase II in human determined in pH-shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition concentration against carbonic anhydrase II in rat determined in esterase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310430(CHEMBL1084919 | N-[(4-bromo-1-benzothien-3-yl)meth...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310434(CHEMBL1077117 | N-(1-benzofuran-3-ylmethyl)sulfami...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310436(CHEMBL1084675 | N-[(5-chloro-1-benzothien-3-yl)met...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310429(CHEMBL1088203 | N-(1-naphthylmethyl)sulfamide)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of carbonic anhydrase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310433(CHEMBL1077134 | N-[(2-methyl-1-benzofuran-3-yl)met...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310431(CHEMBL1084918 | N-[(5-fluoro-1-benzothien-3-yl)met...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rattus norvegicus (Rat))
Janssen Pharmaceutical Companies Of Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50444089(CHEMBL3092995)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of rat Cav2.2-mediated calcium flux expressed in HEK cells by FDSS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310438(CHEMBL1086777 | N-[(5-methyl-1-benzothien-3-yl)met...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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