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Found 52 with Last Name = 'sneddon' and Initial = 'sf'
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285792(4-Oxo-piperidine-1-carboxylic acid {(S)-1-[(R)-1-(...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285798(4-Oxo-piperidine-1-carboxylic acid ({(R)-1-[(1S,2R...)
Affinity DataIC50:  66nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285794(4-Oxo-piperidine-1-carboxylic acid {[(R)-1-((1S,2R...)
Affinity DataIC50:  110nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285796(4-Oxo-piperidine-1-carboxylic acid {[(R)-1-((1S,2R...)
Affinity DataIC50:  130nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285791((R)-2-Acetylamino-N-((1S,2R,3S)-1-biphenyl-4-ylmet...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285799(4-Oxo-piperidine-1-carboxylic acid {[(R)-1-((1S,2R...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285797((R)-2-Acetylamino-N-((1S,2R,3S)-1-biphenyl-3-ylmet...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285795((R)-2-Acetylamino-N-((1S,2R,3S)-1-cyclohexylmethyl...)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetRenin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50285793(4-Oxo-piperidine-1-carboxylic acid {[(R)-1-((1S,2R...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition against recombinant human renin (rHR)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164974((S)-2-(3,4-Dichloro-benzoyl)-1,2,3,4-tetrahydro-is...)
Affinity DataEC50:  82nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164975((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  230nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164976((S)-2-(5-Cyclohexyloxy-pyridine-3-carbonyl)-1,2,3,...)
Affinity DataEC50:  35nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164979((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  100nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164980((S)-2-(4-Cyclohexyloxy-pyridine-2-carbonyl)-1,2,3,...)
Affinity DataEC50:  9.40nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164977((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  41nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164978((R)-2-(3-Phenylsulfanyl-benzoyl)-1,2,3,4-tetrahydr...)
Affinity DataEC50:  394nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164981((S)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  119nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164983(2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoquinol...)
Affinity DataEC50:  294nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164985((S)-2-(3-Ethoxy-benzoyl)-1,2,3,4-tetrahydro-isoqui...)
Affinity DataEC50:  26nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164986((S)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  53nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164987((R)-2-(2-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  338nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164989((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  336nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164991((S)-2-(4-Isopropoxy-pyridine-2-carbonyl)-1,2,3,4-t...)
Affinity DataEC50:  6nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164990((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  202nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164994((S)-2-(3-Isobutoxy-benzoyl)-1,2,3,4-tetrahydro-iso...)
Affinity DataEC50:  10nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165003((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  420nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164995((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  61nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164998((R)-2-[3-(4-Methoxy-phenoxy)-benzoyl]-1,2,3,4-tetr...)
Affinity DataEC50:  167nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164997((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  202nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165004((S)-2-(4-Methoxy-3-phenoxy-benzoyl)-1,2,3,4-tetrah...)
Affinity DataEC50:  12nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165001((S)-2-(4-Phenoxy-pyridine-2-carbonyl)-1,2,3,4-tetr...)
Affinity DataEC50:  20nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165007((S)-2-(3-Chloro-benzoyl)-1,2,3,4-tetrahydro-isoqui...)
Affinity DataEC50:  51nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164982((R)-2-[3-(4-Trifluoromethyl-phenoxy)-benzoyl]-1,2,...)
Affinity DataEC50:  282nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164984((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  160nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164988((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  71nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164992((S)-2-(3-Cyclopentyloxy-benzoyl)-1,2,3,4-tetrahydr...)
Affinity DataEC50:  15nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164993((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  66nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165000((S)-2-(3-Isopropoxy-4-methoxy-benzoyl)-1,2,3,4-tet...)
Affinity DataEC50:  3.5nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164996((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  66nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164999((S)-2-(5-Isopropoxy-pyridine-3-carbonyl)-1,2,3,4-t...)
Affinity DataEC50:  16nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165005((S)-2-(2-Isopropoxy-pyridine-4-carbonyl)-1,2,3,4-t...)
Affinity DataEC50:  11nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165002((S)-2-(4-Chloro-pyridine-2-carbonyl)-1,2,3,4-tetra...)
Affinity DataEC50:  79nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164973((R)-2-[3-(4-Fluoro-phenoxy)-benzoyl]-1,2,3,4-tetra...)
Affinity DataEC50:  590nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164972((R)-2-(3-Benzyl-benzoyl)-1,2,3,4-tetrahydro-isoqui...)
Affinity DataEC50:  291nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164971((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  145nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164970((R)-2-[3-(Pyridin-2-yloxy)-benzoyl]-1,2,3,4-tetrah...)
Affinity DataEC50:  268nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164969((S)-2-(3-Methoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  176nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164967((R)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  292nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50164968((S)-2-(3-Cyclohexyloxy-benzoyl)-1,2,3,4-tetrahydro...)
Affinity DataEC50:  20nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCystic fibrosis transmembrane conductance regulator(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50165006((S)-2-(3-Phenoxy-benzoyl)-1,2,3,4-tetrahydro-isoqu...)
Affinity DataEC50:  23nMAssay Description:Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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