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Found 549 with Last Name = 'snow' and Initial = 'l'
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity to 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50001775((ritanserin)6-(2-{4-[Bis-(4-fluoro-phenyl)-methyle...)
Affinity DataKi:  0.710nMAssay Description:Binding affinity to 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529935(COCHLIOQUINONE A)
Affinity DataKi:  2.26E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529935(COCHLIOQUINONE A)
Affinity DataKi:  2.26E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529932(STEMPHONE)
Affinity DataKi:  3.32E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529932(STEMPHONE)
Affinity DataKi:  3.32E+3nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529934(ETHYLENE GLYCOL DIOCTANOATE)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529934(ETHYLENE GLYCOL DIOCTANOATE)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529937(CHEBI:75342 | Glyceryl monooleate)
Affinity DataKi:  9.10E+4nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase alpha(Homo sapiens)
University Of Piemonte Orientale

Curated by ChEMBL
LigandPNGBDBM50529937(CHEBI:75342 | Glyceryl monooleate)
Affinity DataKi:  9.10E+4nMAssay Description:Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151740((3S,4R)-3-Hydroxy-4-(4''-methyl-biphenyl-4-sulfony...)
Affinity DataIC50:  0.390nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151751(3-Hydroxy-4-(3''-methyl-biphenyl-4-sulfonyl)-tetra...)
Affinity DataIC50:  0.430nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168742((2R,3R)-3-Hydroxy-3-methyl-1-[4-(quinolin-8-ylmeth...)
Affinity DataIC50:  0.480nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167611((2R,5R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151734((3S,4R)-4-[4-(4-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  0.880nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151732(4-[4-(2,4-Dichloro-benzyloxy)-benzenesulfonyl]-3-h...)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of matrix metalloprotease 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151732(4-[4-(2,4-Dichloro-benzyloxy)-benzenesulfonyl]-3-h...)
Affinity DataIC50:  0.950nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24922(5-(carbamoylamino)-3-{6,7,8,9-tetrahydro-5H-benzo[...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50118975(4-(4-Methoxy-benzenesulfonyl)-1-(thiophene-2-carbo...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of matrix metalloprotease-13.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24923(5-(carbamoylamino)-3-[(5R)-6,7,8,9-tetrahydro-5H-b...)
Affinity DataIC50: <1nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168737((2R,3R)-1-[4-(2-Chloro-4-fluoro-benzyloxy)-benzene...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against MMP-8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151736(3-Hydroxy-4-(4-p-tolyloxy-benzenesulfonyl)-tetrahy...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151741((3S,4R)-3-Hydroxy-4-(4-m-tolyloxy-benzenesulfonyl)...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167619((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benz...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151738(3-Hydroxy-4-[4-(4-methyl-benzyloxy)-benzenesulfony...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167618((2R,5R)-1-[4-(4-Bromo-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168743((2R,3R)-1-[4-(3-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  1.60nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168758((2R,3S)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenes...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration of the compound against rat TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168738((2R,3R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  1.90nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167620((2R,5R)-1-[4-(5-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  2.10nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168752((2R,3R)-3-Hydroxy-3-methyl-1-[4-(2-methyl-benzylox...)
Affinity DataIC50:  2.20nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151746(4-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]-3-hydro...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168741((2R,3R)-1-[4-(4-Fluoro-2-methyl-benzyloxy)-benzene...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168756((2R,3R)-3-Hydroxy-1-[4-(isoquinolin-8-ylmethoxy)-b...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against TNF-alpha release in LPS treated whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50151733((3S,4R)-4-[4-(2-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration against matrix metalloprotease 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167621((2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(3-methyl-benz...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory concentration against Matrix metalloproteinase-13 (MMP-13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172252(CHEMBL3809526)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172322(CHEMBL3809288)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172323(CHEMBL3810252)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Pfizer

LigandPNGBDBM24899(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-[(methylca...)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172327(CHEMBL3808860)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172243(CHEMBL3103192)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172250(CHEMBL3809024)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50172249(CHEMBL3809915)
Affinity DataIC50: <3nMAssay Description:Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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