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Found 35 with Last Name = 'soares' and Initial = 'j'
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50126186(2-(3-Naphthalen-2-yl-but-2-enoylamino)-benzoic aci...)
Affinity DataIC50:  93nMAssay Description:Inhibition of human telomerase isolated from human HeLa cells nuclear extracts expressed in insect cells assessed as [33P]dCMP incorporation after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446424(CHEMBL1256678 | U-73122)
Affinity DataIC50:  200nMAssay Description:Inhibition of human telomerase activity in human Jurkat cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446426(CHEMBL3109742)
Affinity DataIC50:  400nMAssay Description:Inhibition of human telomerase activity after 8 mins by SYBR Green staining-based TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446421(CHEMBL3109740)
Affinity DataIC50:  470nMAssay Description:Inhibition of human telomerase isolated from human HeLa cells nuclear extracts expressed in insect cells assessed as [33P]dCMP incorporation after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  500nMAssay Description:Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446422(CHEMBL2164966 | Rel-Chrolactomycin)
Affinity DataIC50:  500nMAssay Description:Inhibition of human telomerase isolated from human A431 cellular extracts after 30 mins by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM22857(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Affinity DataIC50:  500nMAssay Description:Inhibition of pre-assembled human recombinant telomerase activity in rabbit reticulocytes after 90 mins by gel electrophoresis method based direct pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50431275(CARMOFUR | Carm-ofur | Mifurol | med.21724, Compou...)
Affinity DataIC50:  670nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50396097(CHEMBL2170856)
Affinity DataIC50:  670nMAssay Description:Inhibition of human telomerase isolated from human U937 cellular extracts by SYBR Green staining-based TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50426071(CHEMBL406050 | PX-12 | US9018255, PX-12 | med.2172...)
Affinity DataIC50:  670nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataIC50:  670nMAssay Description:Inhibition of SARS-CoV-2 3CL proteaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTelomerase reverse transcriptase(Rattus norvegicus)
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446425(CHEMBL3109741)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rat telomerase by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50446423(CHEMBL3109739)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of human telomerase activity by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50444911(CHEMBL3099733)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of human telomerase isolated from human A431 cellular extracts after 30 mins by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50396098(CHEMBL2170857)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human telomerase activity by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276827(CHEMBL448813 | N,N',N'',N'''-(9,9'-(hexane-1,6-diy...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM22857(1,2-Dione-Based Compound, 14 | 9,10-dihydrophenant...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant telomerase activity in rabbit reticulocytes after 90 mins by telomerase assemblage gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM83922(1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]be...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant telomerase activity in rabbit reticulocytes after 90 mins by telomerase assemblage gel electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276829(CHEMBL443702 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276828(CHEMBL506865 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human telomerase assessed as unincorporated [alpha32P]dGTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtection of telomeres protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276829(CHEMBL443702 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50346373((2S,5S,8S,11S)-8-(2-carboxyethyl)-11-(carboxymethy...)
Affinity DataIC50:  1.34E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)TBA
LigandPNGBDBM50058655(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Affinity DataIC50:  1.46E+4nMAssay Description:Inhibition of recombinant MERS-CoV PL protease using Ub-AFC incubated for 3 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326100((S)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtection of telomeres protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276827(CHEMBL448813 | N,N',N'',N'''-(9,9'-(hexane-1,6-diy...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326101((S)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-...)
Affinity DataIC50:  2.37E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM50058655(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Affinity DataIC50:  2.41E+4nMAssay Description:Inhibition of recombinant SARS CoV-2 PL protease using Ub-AFC incubated for 3 mins by fluorescence based analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326093((S)-3-((2S,3S)-2-(benzyloxycarbonylamino)-3-methyl...)
Affinity DataIC50:  2.83E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326096((S)-3-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylam...)
Affinity DataIC50:  2.99E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326095((S)-3-((2S,3S)-2-(benzyloxycarbonylamino)-3-methyl...)
Affinity DataIC50:  3.05E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326097((S)-3-((S)-2-(((9H-fluoren-9-yl)methoxy)carbonylam...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
University Of Lisbon

Curated by ChEMBL
LigandPNGBDBM50326094((S)-3-((S)-2-(benzyloxycarbonylamino)-3-methylbuta...)
Affinity DataIC50:  3.53E+4nMAssay Description:Inhibition of human recombinant caspase-3 expressed in Saccharomyces cerevisiae CG379 assessed as growth stimulation after 2 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtection of telomeres protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50276828(CHEMBL506865 | N,N',N'',N'''-(9,9'-(ethane-1,2-diy...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtection of telomeres protein 1(Homo sapiens (Human))
University Of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50134030(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Affinity DataIC50:  6.30E+4nMAssay Description:Inhibition of human 35S-labeled Pot1 binding to human telomeric DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed