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Found 1303 with Last Name = 'sparks' and Initial = 's'
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502507(CHEMBL4475659)
Affinity DataIC50: <2nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502502(CHEMBL4528905)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27747((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Affinity DataIC50:  3nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27730((2S,3R)-3-(tert-butoxy)-2-{[4-(4-methoxyphenyl)-2-...)
Affinity DataIC50:  3nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27743((2S,3R)-3-(tert-butoxy)-2-{[2-({[4-(cyclopropylmet...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27746((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27745((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  4nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502506(CHEMBL4460841)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)
Affinity DataIC50:  5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256329(1-(3-(3-mesitylureido)-2-naphthamido)cyclooctaneca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50255975((S)-2-cyclohexyl-2-(3-(3-(2,6-dichloro-4-(trifluor...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM28661(2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)
Affinity DataIC50:  5nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50255977((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256669((2S,3R)-2-(3-(3-mesitylureido)-2-naphthamido)-3-(1...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418124(CHEMBL1760428)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27726((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1802(2-Amino-6-arylthiobenzonitrile deriv. 3v, 739W94 |...)
Affinity DataIC50:  7nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27726((2S,3R)-3-(tert-butoxy)-2-[(3-{[(2,4,6-trimethylph...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27734((2S,3R)-3-(tert-butoxy)-2-{[4-(4-fluorophenyl)-2-{...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27744((2S,3R)-3-(tert-butoxy)-2-{[4-(3,4-difluorophenyl)...)
Affinity DataIC50:  7nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418148(CHEMBL1760411)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mouse FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 4(Rattus norvegicus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50044874(CHEMBL3311302)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of rat FFA4 receptor expressed in U2OS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27731((2S,3R)-3-(tert-butoxy)-2-{[4-(3-methoxyphenyl)-2-...)
Affinity DataIC50:  8nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502516(CHEMBL4470436)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256573((S)-2-(3-(3-mesitylureido)-2-naphthamido)-5-methyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502509(CHEMBL4548610)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1805(2-Amino-6-arylthiobenzonitrile deriv. 3y | 2-amino...)
Affinity DataIC50:  10nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256169((S)-2-cyclohexyl-2-(3-(3-mesitylureido)-2-naphtham...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27742((2S,3R)-3-(tert-butoxy)-2-[(2-{[(2,6-dimethyl-4-pr...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27729((2S,3R)-3-(tert-butoxy)-2-[(4-phenyl-2-{[(2,4,6-tr...)
Affinity DataIC50:  10nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502517(CHEMBL4458025)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27735((2S,3R)-3-(tert-butoxy)-2-{[4-(3,4-difluorophenyl)...)
Affinity DataIC50:  13nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256071(2-(4,4-difluorocyclohexyl)-2-(3-(3-mesitylureido)-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418129(CHEMBL1760268)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27740((2S)-2-cyclohexyl-2-{[2-({[4-(cyclopropylmethyl)-2...)
Affinity DataIC50:  13nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256330(1-(3-(3-mesitylureido)-2-naphthamido)cyclodecaneca...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256012((S)-2-cyclopentyl-2-(3-(3-mesitylureido)-2-naphtha...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence intensity endpoint assay in presence of glucoseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27733((2S,3R)-3-(tert-butoxy)-2-{[4-(3-fluorophenyl)-2-{...)
Affinity DataIC50:  15nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256710((2S,3R)-3-(benzyloxy)-2-(3-(3-mesitylureido)-2-nap...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502510(CHEMBL4474610)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418123(CHEMBL1760005)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418161(CHEMBL1760424)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50418135(CHEMBL1760274)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]GW 2433 from human PPARdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256667((2S,3R)-3-isopropoxy-2-(3-(3-mesitylureido)-2-naph...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502504(CHEMBL4582349)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM50256668((2S,3R)-3-cyclobutoxy-2-(3-(3-mesitylureido)-2-nap...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human liver glycogen phosphorylase A by fluorescence plate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Selenity Therapeutics

Curated by ChEMBL
LigandPNGBDBM50502508(CHEMBL4476620)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant CYP11B2 using deoxycorticosterone as substrate incubated for 90 mins by cell-based HPLC analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen phosphorylase, liver form(Homo sapiens (Human))
Gsk

LigandPNGBDBM27739((2S)-2-cyclohexyl-2-[(2-{[(2,6-dimethyl-4-propylph...)
Affinity DataIC50:  19nMpH: 7.6 T: 2°CAssay Description:An enzymatic assay was developed to measure the response of the activated form of glycogen phosphorylase to small molecule compounds. The assay was t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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