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Found 259 with Last Name = 'spear' and Initial = 'n'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50156071(3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]-MPEP from human mGluR5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50331975(1-(4-(2-chloro-4-fluorophenyl)piperazin-1-yl)-2-(p...)
Affinity DataKi:  2.37E+3nMAssay Description:Displacement of [3H]-MPEP from human mGluR5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363338(CHEMBL1946023)
Affinity DataIC50:  0.0820nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363340(CHEMBL1946025)
Affinity DataIC50:  0.160nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363344(CHEMBL1946029)
Affinity DataIC50:  0.170nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363330(CHEMBL1946016)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363341(CHEMBL1946026)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363335(CHEMBL1946020)
Affinity DataIC50:  0.220nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363336(CHEMBL1946021)
Affinity DataIC50:  0.25nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363333(CHEMBL1944652)
Affinity DataIC50:  0.260nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363342(CHEMBL1946027)
Affinity DataIC50:  0.270nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363348(CHEMBL1946618)
Affinity DataIC50:  0.280nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363343(CHEMBL1946028)
Affinity DataIC50:  0.390nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50092711(CHEMBL339457 | N,N-Diethyl-4-[(3-fluoro-phenyl)-pi...)
Affinity DataIC50:  0.440nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363334(CHEMBL1946019)
Affinity DataIC50:  0.450nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363327(CHEMBL1946620)
Affinity DataIC50:  0.460nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363347(CHEMBL1946617)
Affinity DataIC50:  0.630nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363345(CHEMBL1946615)
Affinity DataIC50:  0.670nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363331(CHEMBL1946017)
Affinity DataIC50:  0.700nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363339(CHEMBL1946024)
Affinity DataIC50:  0.75nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363329(CHEMBL1946015)
Affinity DataIC50:  0.780nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363337(CHEMBL1946022)
Affinity DataIC50:  1.80nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363326(CHEMBL1946619)
Affinity DataIC50:  2.40nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363328(CHEMBL1946621)
Affinity DataIC50:  2.70nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363346(CHEMBL1946616)
Affinity DataIC50:  3.40nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276409((1S,2S)-N-(2-methoxyethyl)-2-(thiophen-3-yl)-1,2,3...)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363338(CHEMBL1946023)
Affinity DataIC50:  33nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276496(3-chloro-N-(2-methoxyethyl)-N-((1R,2R)-2-(4-phenyl...)
Affinity DataIC50:  58nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363335(CHEMBL1946020)
Affinity DataIC50:  63nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276363((+/-)-N-(2-methoxyethyl)-2-(thiophen-3-yl)-1,2,3,4...)
Affinity DataIC50:  69nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226448((6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276495((+/-)-3-chloro-N-(2-methoxyethyl)-N-(2-(4-phenylpi...)
Affinity DataIC50:  100nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276411((+/-)-N-(2-methoxyethyl)-N-(2-(4-phenylpiperazin-1...)
Affinity DataIC50:  126nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363341(CHEMBL1946026)
Affinity DataIC50:  140nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276445((+/-)-N-(2-methoxyethyl)-2-(3-methoxyphenyl)-N-(2-...)
Affinity DataIC50:  151nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276497((+/-)-2-(4-chlorophenoxy)-N-(2-(dimethylamino)-6,7...)
Affinity DataIC50:  155nMAssay Description:Displacement of [125I]U69593 from human cloned kappa opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363336(CHEMBL1946021)
Affinity DataIC50:  170nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363340(CHEMBL1946025)
Affinity DataIC50:  180nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276446((+/-)-2-(4-chlorophenyl)-N-(2-methoxyethyl)-N-(2-(...)
Affinity DataIC50:  181nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226454(2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-d...)
Affinity DataIC50:  200nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363346(CHEMBL1946616)
Affinity DataIC50:  200nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50363332(CHEMBL1946018)
Affinity DataIC50:  200nMAssay Description:Displacement of radiolabeled iodinated deltorphin 2 from delta opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276444((+/-)-2-(benzyloxy)-N-(2-methoxyethyl)-N-(2-(4-phe...)
Affinity DataIC50:  211nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363347(CHEMBL1946617)
Affinity DataIC50:  220nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276497((+/-)-2-(4-chlorophenoxy)-N-(2-(dimethylamino)-6,7...)
Affinity DataIC50:  245nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363343(CHEMBL1946028)
Affinity DataIC50:  330nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363342(CHEMBL1946027)
Affinity DataIC50:  340nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50363344(CHEMBL1946029)
Affinity DataIC50:  350nMAssay Description:Displacement of radiolabeled FK33-824 from mu opioid receptor expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Toronto

Curated by ChEMBL
LigandPNGBDBM50276498((+/-)-3,4-dichloro-N-(2-(dimethylamino)-6,7-dimeth...)
Affinity DataIC50:  351nMAssay Description:Displacement of [125I]FK33824 from human cloned mu opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astrazeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50226442(2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5...)
Affinity DataIC50:  380nMAssay Description:Inhibition of BACE1 by FRET assayMore data for this Ligand-Target Pair
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