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Found 192 with Last Name = 'spero' and Initial = 'dm'
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208836((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-4-...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196941(CHEMBL246365 | N2-(2-chlorobenzyl)-N4-((3-(aminome...)
Affinity DataIC50:  3nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121562(CHEMBL153239 | Morpholine-4-carboxylic acid [1-(1-...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121542(CHEMBL155560 | Thiophene-2-carboxylic acid {1-[(be...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196957(CHEMBL246175 | N2-(2-bromobenzyl)-N4-((4-(aminomet...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196932(CHEMBL392642 | N2-(2-(methylthio)benzyl)-N4-((4-(a...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121554(CHEMBL356155 | N-{1-[(Benzyloxymethyl-cyano-methyl...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196961(CHEMBL246174 | N2-(2-(trifluoromethylthio)benzyl)-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121549(CHEMBL347111 | Morpholine-4-carboxylic acid {1-[(b...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196936(CHEMBL246386 | N2-(2,5-dichlorobenzyl)-N4-((4-(ami...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121575(CHEMBL356442 | Morpholine-4-carboxylic acid (1-{[c...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121569(CHEMBL153783 | Morpholine-4-carboxylic acid {1-[(b...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196978(CHEMBL246183 | N2-(2,3-dichlorobenzyl)-N4-((4-(ami...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121581(CHEMBL150253 | Morpholine-4-carboxylic acid (1-{[(...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121543(CHEMBL435440 | Morpholine-4-carboxylic acid {1-[(c...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121561(CHEMBL356167 | Morpholine-4-carboxylic acid (1-{[(...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121545(CHEMBL149523 | Morpholine-4-carboxylic acid (1-{[(...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121544(CHEMBL153248 | Pyrazine-2-carboxylic acid {1-[(ben...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196959(CHEMBL396929 | N2-(2-nitrobenzyl)-N4-((4-(aminomet...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196951(CHEMBL247979 | N2-(2-(trifluoromethyl)benzyl)-N4-(...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121558(CHEMBL152940 | Morpholine-4-carboxylic acid (1-{[c...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196987(CHEMBL245912 | N2-(2,3-dimethylbenzyl)-N4-((4-(ami...)
Affinity DataIC50:  13nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208837((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196991(CHEMBL245977 | N2-(2-(difluoromethyl)benzyl)-N4-((...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196952(CHEMBL395690 | N2-(2-methoxybenzyl)-N4-((4-(aminom...)
Affinity DataIC50:  17nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121572(CHEMBL150358 | Morpholine-4-carboxylic acid {1-[(c...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196958(CHEMBL246159 | N2-(2-chlorobenzyl)-N4-(((1s,4s)-4-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196972(CHEMBL248183 | N2-(2-(trifluoromethoxy)benzyl)-N4-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121548(CHEMBL153813 | MORPHOLINE-4-CARBOXYLIC ACID [1S-(2...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121541(CHEMBL346448 | Morpholine-4-carboxylic acid (1-{[c...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121576(CHEMBL153018 | Furan-2-carboxylic acid {1-[(benzyl...)
Affinity DataIC50:  21nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196975(CHEMBL245783 | N2-(2,3-difluorobenzyl)-N4-((4-(ami...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208855((R)-N-((R)-3-cyano-1-(cyclopropylmethyl)pyrrolidin...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208856((R)-N-((R)-3-cyano-1-phenethylpyrrolidin-3-yl)-2-(...)
Affinity DataIC50:  22.3nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121570(CHEMBL348679 | Morpholine-4-carboxylic acid [1-(1-...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208846((R)-N-((R)-3-cyano-1-cyclohexylpyrrolidin-3-yl)-2-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208858((R)-N-((R)-3-cyano-1-cycloheptylpyrrolidin-3-yl)-2...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196990(CHEMBL246184 | N2-(2,4-dichlorobenzyl)-N4-((4-(ami...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121557(CHEMBL151642 | Morpholine-4-carboxylic acid (1-{[(...)
Affinity DataIC50:  27nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196982(CHEMBL395691 | N2-(2-chlorobenzyl)-N4-(((1r,4r)-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208852((R)-N-((S)-1-benzyl-3-cyanopyrrolidin-3-yl)-2-(cyc...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196980(CHEMBL247572 | N4-((4-(aminomethyl)cyclohexyl)meth...)
Affinity DataIC50:  31nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196948(CHEMBL428751 | N*4*-(4-aminomethyl-cyclohexylmethy...)
Affinity DataIC50:  34nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196956(CHEMBL396370 | N2-(2,5-difluorobenzyl)-N4-((4-(ami...)
Affinity DataIC50:  35nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208839((R)-N-((R)-2-(benzyloxy)-1-cyanoethyl)-2-(cyclohex...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196973(CHEMBL438669 | N*4*-(4-aminomethyl-cyclohexylmethy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50196954(CHEMBL246177 | N*4*-(4-aminomethyl-cyclohexylmethy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of PKCtheta by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208849((R)-N-((R)-3-cyano-1-isobutylpyrrolidin-3-yl)-2-(c...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50121551(CHEMBL150574 | Morpholine-4-carboxylic acid [1-(1-...)
Affinity DataIC50:  41nMAssay Description:Inhibitory concentration against human recombinant Cathepsin S expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50208853((R)-N-((S)-3-cyano-1-(cyclohexylmethyl)pyrrolidin-...)
Affinity DataIC50:  41nMAssay Description:Inhibition of human cathepsin SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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