TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 85nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 200nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 290nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 450nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 490nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 1.08E+3nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytesMore data for this Ligand-Target Pair
Affinity DataKi: 3.02E+3nMAssay Description:Inhibition of [3H]diltiazem binding to Sprague-Dawley rat cardiomyocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 1.45E+4nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytesMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataKi: 2.37E+4nMAssay Description:Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 740nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
Universita Degli Studi Di Bologna
Curated by ChEMBL
Universita Degli Studi Di Bologna
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of L-type calcium channel in Wistar rat tail artery smooth muscle cells assessed as blockade of barium-sensitive inward rectifying current...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate after 30 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.55E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate after 40 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.84E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate after 20 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.92E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair