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Found 45 with Last Name = 'spooner' and Initial = 'je'
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096484((4S,6R)-6-Allyl-4-(naphthalene-2-sulfonyl)-5-oxo-h...)
Affinity DataIC50:  0.0360nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  0.0470nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  0.450nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096486(CHEMBL2367646 | benzyl (3aS,6aR)-4-acetyl-6-allyl-...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retinaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096487((3R,6aS)-3-Allyl-2-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096483((3R,6aS)-1-Methanesulfonyl-4-(3-piperidin-1-yl-pro...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50061024((2-Methyl-1-{(S)-oxo-[(S)-2-((S)-3,3,3-trifluoro-1...)
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  23nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 0 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096490((3aS,6R)-6-Allyl-4-hexyl-5-oxo-hexahydro-pyrrolo[3...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096485((3aS,6R)-6-Allyl-4-ethylcarbamoyl-5-oxo-hexahydro-...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  36nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067002((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  47nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  56nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066998((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  69nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066996((3S,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  74nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067000((3aS,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-...)
Affinity DataIC50:  88nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096489((3aS,6R)-6-Allyl-4-formyl-5-oxo-hexahydro-pyrrolo[...)
Affinity DataIC50:  94nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096483((3R,6aS)-1-Methanesulfonyl-4-(3-piperidin-1-yl-pro...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067002((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  336nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 0 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067001((3aS,6R)-6-Allyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50: >500nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  980nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066998((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  3.60E+3nMAssay Description:The compound was tested for inhibition of cathepsin G with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066998((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  4.00E+3nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066996((3S,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  4.86E+3nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067000((3aS,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-...)
Affinity DataIC50:  1.15E+4nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066996((3S,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  1.28E+4nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 0 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067002((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  1.59E+4nMAssay Description:The compound was tested for inhition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  4.06E+4nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  4.06E+4nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  4.06E+4nMAssay Description:The compound was tested for inhibition of cathepsin G with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  4.06E+4nMAssay Description:The compound was tested for inhition of thrombin with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066996((3S,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  4.46E+4nMAssay Description:The compound was tested for inhition of thrombin with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067002((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  4.90E+4nMAssay Description:The compound was tested for inhition of thrombin with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066996((3S,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50:  6.70E+4nMAssay Description:The compound was tested for inhibition of cathepsin G with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  7.88E+4nMAssay Description:The compound was tested for inhibition of thrombin with a preincubation time of 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067000((3aS,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of thrombin with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067001((3aS,6R)-6-Allyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of Chymotrypsinogen with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067000((3aS,6R)-6-Allyl-4-(naphthalene-1-sulfonyl)-5-oxo-...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 0 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067001((3aS,6R)-6-Allyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of thrombin with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin G(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067002((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of cathepsin G with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067001((3aS,6R)-6-Allyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066998((3R,6aS)-3-Allyl-2-oxo-hexahydro-furo[3,2-b]pyrrol...)
Affinity DataIC50: >2.00E+5nMAssay Description:The compound was tested for inhition of thrombin with a preincubation time of 15 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50067001((3aS,6R)-6-Allyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50: >5.00E+5nMAssay Description:The compound was tested for inhibition of human neutrophil elastase enzyme with a preincubation time of 40 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed