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Found 275 with Last Name = 'sredy' and Initial = 'j'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16485(2-{6-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50:  5nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16469(2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Affinity DataIC50:  5nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16491(2-{7-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  6nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16488(2-{7-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16482(2-{6-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  7nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)
Affinity DataIC50:  8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16483(2-{6-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16481(2-[5-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Affinity DataIC50:  8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16493(2-{3-[2-(4,5,7-trifluoro-1,3-benzothiazol-2-yl)eth...)
Affinity DataIC50:  8nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16477(2-{5-methoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50:  8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16476(2-{5-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16470(2-{2-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  8nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16464(2-{3-[(5-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Affinity DataIC50:  9nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16489(2-{7-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  9nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16484(2-{6-methyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  10nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16473(2-{5-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  10nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50079859((R)-2-[2,6-Dibromo-4-(6-bromo-benzo[b]naphtho[2,3-...)
Affinity DataIC50:  11nMAssay Description:The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase 1B (human PTPases.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16474(2-{5-fluoro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16472(2-{4-chloro-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  11nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16478(2-[5-(benzyloxy)-3-[(4,5,7-trifluoro-1,3-benzothia...)
Affinity DataIC50:  12nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16475(2-{5-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)
Affinity DataIC50:  13nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  13nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16490(2-{7-bromo-3-[(4,5,7-trifluoro-1,3-benzothiazol-2-...)
Affinity DataIC50:  14nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16487(2-[6-(morpholin-4-yl)-3-[(4,5,7-trifluoro-1,3-benz...)
Affinity DataIC50:  15nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16494(3-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Affinity DataIC50:  17nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086986(2-[4'-(2-Benzyl-benzofuran-3-yl)-3,5-dibromo-biphe...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086896(4-[4''-(2-Benzyl-benzo[b]thiophen-3-yl)-3-bromo-bi...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50010062(CHEMBL84152 | [(2-Fluoro-6-methoxy-5-trifluorometh...)
Affinity DataIC50:  25nMAssay Description:Inhibition of aldose reductase activity of the compound was measured on partially purified bovine lens preparations incubated in presense of 50 mM gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086947(2-[4'-(2-Benzyl-benzo[b]thiophen-3-yl)-3,5-dibromo...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086972(2-{4-[4-(2-benzyl-1-benzothiophen-3-yl)phenyl]-2,6...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086950(2-[4-[4-(2-benzylbenzo[b]thiophen-3-yl)phenyl]-2,6...)
Affinity DataIC50:  25nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16486(2-{6-phenyl-3-[(4,5,7-trifluoro-1,3-benzothiazol-2...)
Affinity DataIC50:  25nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086911(5-[4''-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxy...)
Affinity DataIC50:  26nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086970(4-[4'-(2-Benzyl-benzo[b]thiophen-3-yl)-biphenyl-4-...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086975(Benzothiophene derivative | CHEMBL25628 | [4-(2-Be...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086923(4-[4''-(2-Benzyl-benzofuran-3-yl)-3-cyclopentyl-bi...)
Affinity DataIC50:  28nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086954(CHEMBL278092 | [4-(2-Benzyl-benzo[b]thiophen-3-yl)...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086981(4-[4''-(2-Benzyl-benzofuran-3-yl)-3-nitro-biphenyl...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086955(4-[4''-(2-Benzyl-benzo[b]thiophen-3-yl)-3,5-dibrom...)
Affinity DataIC50:  30nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16479(2-{5-phenoxy-3-[(4,5,7-trifluoro-1,3-benzothiazol-...)
Affinity DataIC50:  30nMAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086951(4-[4'-(2-Benzyl-4,5-dimethyl-thiophen-3-yl)-biphen...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  34nMAssay Description:inhibition of aldose reductase activity of the compound was measured on partially purified bovine lens preparations incubated in presense of 50 mM gl...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086902(4-[4''-(2-Benzyl-benzofuran-3-yl)-3,5-dimethyl-bip...)
Affinity DataIC50:  34nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
The Institute For Diabetes Discovery

LigandPNGBDBM16463(2-{3-[(4-fluoro-1,3-benzothiazol-2-yl)methyl]-1H-i...)
Affinity DataIC50:  34nMpH: 6.6 T: 2°CAssay Description:The activity of the test enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappear...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of bovine lens aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  35nMAssay Description:In vitro inhibition of aldose reductase from the partially purified bovine lensMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50009777((ponalrestat)[3-(4-Bromo-2-fluoro-benzyl)-4-oxo-3,...)
Affinity DataIC50:  37nMAssay Description:In vitro Inhibition of aldose reductase was measured in isolated partially purified bovine lens preparations at 10e-7 M concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086892(2-[4'-(2-Benzyl-benzofuran-3-yl)-3,5-dibromo-biphe...)
Affinity DataIC50:  38nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50086963(4-[4'-(2-Benzyl-benzofuran-3-yl)-biphenyl-4-yloxys...)
Affinity DataIC50:  39nMAssay Description:In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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