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Found 124 with Last Name = 'steen' and Initial = 'jt'
LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  0.0600nM ΔG°:  -58.3kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244145(US9428492, 15)
Affinity DataKi:  0.0900nM ΔG°:  -57.3kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244137(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Affinity DataKi:  0.130nM ΔG°:  -56.4kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244127(US9428492, 6 | US9428492, 6a | US9428492, 6b)
Affinity DataKi:  0.170nM ΔG°:  -55.8kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244137(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Affinity DataKi:  0.210nM ΔG°:  -55.2kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244117(US9428492, 1 | US9428492, 2)
Affinity DataKi:  0.230nM ΔG°:  -55.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244142(US9428492, 12)
Affinity DataKi:  0.340nM ΔG°:  -54.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244124(US9428492, 5 | US9428492, 5a | US9428492, 5b)
Affinity DataKi:  0.340nM ΔG°:  -54.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244127(US9428492, 6 | US9428492, 6a | US9428492, 6b)
Affinity DataKi:  0.360nM ΔG°:  -53.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244148(US9428492, 18)
Affinity DataKi:  0.360nM ΔG°:  -53.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244137(US9428492, 10 | US9428492, 10a | US9428492, 10b)
Affinity DataKi:  0.390nM ΔG°:  -53.7kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244124(US9428492, 5 | US9428492, 5a | US9428492, 5b)
Affinity DataKi:  0.410nM ΔG°:  -53.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244121(US9428492, 4 | US9428492, 4a | US9428492, 4b)
Affinity DataKi:  0.410nM ΔG°:  -53.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244154(US9428492, 21)
Affinity DataKi:  0.470nM ΔG°:  -53.2kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244157(US9428492, C)
Affinity DataKi:  0.490nM ΔG°:  -53.1kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244121(US9428492, 4 | US9428492, 4a | US9428492, 4b)
Affinity DataKi:  0.510nM ΔG°:  -53.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244133(US9428492, 8 | US9428492, 8a | US9428492, 8b)
Affinity DataKi:  0.530nM ΔG°:  -52.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244151(US9428492, 20 | US9428492, 20a | US9428492, 20b)
Affinity DataKi:  0.550nM ΔG°:  -52.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244149(US9428492, 19 | US9428492, 19a)
Affinity DataKi:  0.550nM ΔG°:  -52.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244151(US9428492, 20 | US9428492, 20a | US9428492, 20b)
Affinity DataKi:  0.580nM ΔG°:  -52.7kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244159(US9428492, 19b)
Affinity DataKi:  0.590nM ΔG°:  -52.7kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244146(US9428492, 16)
Affinity DataKi:  0.620nM ΔG°:  -52.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244140(US9428492, 11a | US9428492, 11b)
Affinity DataKi:  0.650nM ΔG°:  -52.4kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244143(US9428492, 13)
Affinity DataKi:  0.740nM ΔG°:  -52.1kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244124(US9428492, 5 | US9428492, 5a | US9428492, 5b)
Affinity DataKi:  0.770nM ΔG°:  -52.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244133(US9428492, 8 | US9428492, 8a | US9428492, 8b)
Affinity DataKi:  0.830nM ΔG°:  -51.8kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244151(US9428492, 20 | US9428492, 20a | US9428492, 20b)
Affinity DataKi:  0.920nM ΔG°:  -51.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244133(US9428492, 8 | US9428492, 8a | US9428492, 8b)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244119(US9428492, 3 | US9428492, 3a | US9428492, 3b)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244144(US9428492, 14)
Affinity DataKi:  1.10nM ΔG°:  -51.1kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244136(US9428492, 9)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244117(US9428492, 1 | US9428492, 2)
Affinity DataKi:  1.20nM ΔG°:  -50.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244149(US9428492, 19 | US9428492, 19a)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244121(US9428492, 4 | US9428492, 4a | US9428492, 4b)
Affinity DataKi:  1.80nM ΔG°:  -49.9kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244156(US9428492, B)
Affinity DataKi:  2.10nM ΔG°:  -49.5kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244130(US9428492, 7 | US9428492, 7a | US9428492, 7b)
Affinity DataKi:  2.5nM ΔG°:  -49.1kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244127(US9428492, 6 | US9428492, 6a | US9428492, 6b)
Affinity DataKi:  2.60nM ΔG°:  -49.0kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244147(US9428492, 17)
Affinity DataKi:  2.80nM ΔG°:  -48.8kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244140(US9428492, 11a | US9428492, 11b)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244130(US9428492, 7 | US9428492, 7a | US9428492, 7b)
Affinity DataKi:  3.20nM ΔG°:  -48.5kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244155(US9428492, A)
Affinity DataKi:  4.20nM ΔG°:  -47.8kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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LigandPNGBDBM244130(US9428492, 7 | US9428492, 7a | US9428492, 7b)
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.2 T: 2°CAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, S...More data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM12133(3-(Indol-2-yl)indazole 23 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  0.110nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM12134(2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-...)
Affinity DataIC50:  0.25nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM12132(3-(Indol-2-yl)indazole 22 | [5-(3-{5-[(4-fluoropip...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM12131((5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-...)
Affinity DataIC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM50220886(5-(3-aminopropyl)-7,8-dicyclohexyl-3-methyl-2H-pyr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
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TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM92404(CHEMBL250843 | PDK1 inhibitor, 5)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Chk1 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM12112(1-[4-({2-[6-(1H-1,2,3,4-tetrazol-5-yl)-1H-indazol-...)
Affinity DataIC50:  2.30nMpH: 7.5 T: 2°CAssay Description:Kinase activity was measured in a homogeneous assay in a 96-well format. Detection was performed by HTRF using an EuK-labelled anti-phospho(S21)-GSK3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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