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Found 120 with Last Name = 'stefek' and Initial = 'm'
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataKi:  17nMAssay Description:Uncompetitive inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldeh...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataKi:  66nMAssay Description:Uncompetitive inhibition of recombinant human AKR1B1 using D,L-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataKi:  89nMAssay Description:Uncompetitive inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate by double reciprocal plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50478795(CHEMBL476908)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 using NADPH as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50478794(CHEMBL477942)
Affinity DataKi:  1.10E+4nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 using NADPH as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50478795(CHEMBL476908)
Affinity DataKi:  1.77E+4nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 using D,L-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50478794(CHEMBL477942)
Affinity DataKi:  1.79E+4nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2 using D,L-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16469(2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435110(CHEMBL2391535)
Affinity DataIC50:  20nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50435110(CHEMBL2391535)
Affinity DataIC50:  21nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human AKR1B1 using D,L-glyceraldehyde as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B7(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant AKR1B1 using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451731(CHEMBL4216153)
Affinity DataIC50:  58nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451731(CHEMBL4216153)
Affinity DataIC50:  58nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant human AKR1B1 using D,L-glyceraldehyde as substrateMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  97nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080464(ALR2 inhibitor, 12 | CHEMBL1405739)
Affinity DataIC50:  98nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451735(CHEMBL4207499)
Affinity DataIC50:  141nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451735(CHEMBL4207499)
Affinity DataIC50:  141nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451730(CHEMBL4207775)
Affinity DataIC50:  169nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  227nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  249nMAssay Description:Inhibition of aldose reductase in rat lensesMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  250nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080469(CHEMBL3422332)
Affinity DataIC50:  324nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080469(CHEMBL3422332)
Affinity DataIC50:  330nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50451733(CHEMBL1897400)
Affinity DataIC50:  340nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50336704((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  390nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50336708((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl)(...)
Affinity DataIC50:  400nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50560035(CHEMBL4784848)
Affinity DataIC50:  980nMAssay Description:Inhibition of Fischer 344 rat eye lens ALR2 using D,L-glyceraldehyde as substrate measured up to 4 mins at 30 degC using NaHCO3/DMSO-dissolved compou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50336705((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50336703((1-(3,5-Difluoro-4-hydroxyphenyl)-1H-pyrrol-2-yl)(...)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50336702(CHEMBL1673033 | [1-(2,4-Difluoro-3-hydroxyphenyl)-...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of rat lens ALR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080465(CHEMBL3422329)
Affinity DataIC50:  2.04E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080465(CHEMBL3422329)
Affinity DataIC50:  2.05E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080466(CHEMBL3422330)
Affinity DataIC50:  2.19E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080466(CHEMBL3422330)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080471(CHEMBL1984484)
Affinity DataIC50:  2.75E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080472(CHEMBL3422326)
Affinity DataIC50:  2.87E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080468(CHEMBL3422331)
Affinity DataIC50:  4.06E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080468(CHEMBL3422331)
Affinity DataIC50:  4.07E+3nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50560034(CHEMBL4793830)
Affinity DataIC50:  4.51E+3nMAssay Description:Inhibition of Fischer 344 rat eye lens ALR2 using D,L-glyceraldehyde as substrate measured up to 4 mins at 30 degC using NaHCO3/DMSO-dissolved compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50560034(CHEMBL4793830)
Affinity DataIC50:  4.73E+3nMAssay Description:Inhibition of Fischer 344 rat kidney ALR1 using sodium D-glucuronate as substrate measured up to 4 mins at 37 degC using NaHCO3/DMSO-dissolved compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B7(Rattus norvegicus)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50080472(CHEMBL3422326)
Affinity DataIC50:  4.82E+3nMAssay Description:Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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