Compile Data Set for Download or QSAR
maximum 50k data
Found 139 with Last Name = 'steffan' and Initial = 'rj'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119202(CHEMBL99599 | Nonanoic acid [4-(4-{[2-hydroxy-2-(4...)
Affinity DataKi:  140nMAssay Description:Binding affinity of compound against Beta-2 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119195(CHEMBL317003 | {1-[4-(4-{[(R)-2-Hydroxy-2-(4-hydro...)
Affinity DataKi:  180nMAssay Description:Binding affinity of compound against Beta-2 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119195(CHEMBL317003 | {1-[4-(4-{[(R)-2-Hydroxy-2-(4-hydro...)
Affinity DataKi:  240nMAssay Description:Binding affinity of compound against Beta-1 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119202(CHEMBL99599 | Nonanoic acid [4-(4-{[2-hydroxy-2-(4...)
Affinity DataKi:  6.60E+3nMAssay Description:Binding affinity of compound against Beta-1 adrenergic receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157485(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  3nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119183(1-[4-(4-{[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataIC50:  4nMAssay Description:Compound was tested for the antagonistic activity against Beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(RAT)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177595((2S)-5-amino-2-{[(2S)-1-{[(4R,7S,10S,13S,16R)-13-[...)
Affinity DataIC50:  12nMAssay Description:Antagonism of OT-induced response at OT receptor in rat uterine stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157496(4-[1-(2,5-dichlorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  15nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157483(4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157488(4-(7-chloro-1-cyclopentyl-1H-indazol-3-yl)phenol |...)
Affinity DataIC50:  18nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157501(4-[1-isopropyl-7-(trifluoromethyl)-1H-indazol-3-yl...)
Affinity DataIC50:  20nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157498(4-(1-butyl-7-chloro-1H-indazol-3-yl)phenol | CHEMB...)
Affinity DataIC50:  25nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119183(1-[4-(4-{[(S)-2-Hydroxy-3-(4-hydroxy-phenoxy)-prop...)
Affinity DataIC50:  27nMAssay Description:Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157491(4-[1-(2,5-difluorophenyl)-6-hydroxy-1H-indazol-3-y...)
Affinity DataIC50:  31nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157504(4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol | ...)
Affinity DataIC50:  37nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157489(4-[1-(3-fluorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  39nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157500(4-[6-hydroxy-1-(4-methylphenyl)-1H-indazol-3-yl]be...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157503(4-(7-methyl-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  40nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157486(4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL | CH...)
Affinity DataIC50:  48nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157508(4-[1-(3-chlorophenyl)-6-hydroxy-1H-indazol-3-yl]be...)
Affinity DataIC50:  50nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157502(4-(7-chloro-1-propyl-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  52nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157507(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]-3-...)
Affinity DataIC50:  59nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157487(4-(6-hydroxy-1-propyl-1H-indazol-3-yl)benzene-1,3-...)
Affinity DataIC50:  62nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177593((5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  80nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177599(CHEMBL202447 | [2-chloro-4-(3-methyl-pyrazol-1-yl)...)
Affinity DataIC50:  91.5nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  93nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157505(4-[1-(2-hydroxyethyl)-7-(trifluoromethyl)-1H-indaz...)
Affinity DataIC50:  96nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157484(4-(1-benzyl-7-chloro-1H-indazol-3-yl)phenol | CHEM...)
Affinity DataIC50:  105nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  106nMAssay Description:Displacement of [3H]E2 from ERbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157494(4-(1-butyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-d...)
Affinity DataIC50:  112nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157497(4-[6-hydroxy-1-(2,2,2-trifluoroethyl)-1H-indazol-3...)
Affinity DataIC50:  165nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177591(CHEMBL203513 | [2-chloro-4-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  183nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157506(4-[1-benzyl-7-(trifluoromethyl)-1H-indazol-3-yl]ph...)
Affinity DataIC50:  196nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119187(CHEMBL431048 | N-(5-{(S)-3-[(1-{4-[3-(2,5-Difluoro...)
Affinity DataIC50:  268nMAssay Description:Compound was tested for the antagonistic activity against Beta-2 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177597(CHEMBL203739 | [2-bromo-4-(3-methyl-pyrazol-1-yl)-...)
Affinity DataIC50:  296nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157495(4-(1-ethyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-d...)
Affinity DataIC50:  305nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177594(CHEMBL381763 | [2-chloro-4-(5-methyl-pyrazol-1-yl)...)
Affinity DataIC50:  390nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157490(4-[7-chloro-1-(2-hydroxyethyl)-1H-indazol-3-yl]phe...)
Affinity DataIC50:  410nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177598((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50:  413nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157492(4-(1-cyclohexyl-6-hydroxy-1H-indazol-3-yl)benzene-...)
Affinity DataIC50:  443nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177600(CHEMBL205013 | [2-chloro-4-(3-methyl-pyrazol-1-yl)...)
Affinity DataIC50:  475nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50:  493nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157499(4-(1-methyl-6-hydroxy-1H-indazol-3-yl)benzene-1,3-...)
Affinity DataIC50:  622nMAssay Description:Activity at human ERalpha expressed in HAECT1 cells assessed as inhibition of NFkappaB transcriptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177593((5H,11H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-10-yl)...)
Affinity DataIC50:  778nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177601((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50:  933nMAssay Description:Displacement of [3H]AVP from human V2 receptor transfected in LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(RAT)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50:  1.26E+3nMAssay Description:Antagonism of OT-induced response at OT receptor in rat uterine stripsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50157493(4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]ben...)
Affinity DataIC50:  1.30E+3nMAssay Description:Displacement of [3H]E2 from ERalpha ligand binding domainMore data for this Ligand-Target Pair
TargetVasopressin V1a receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177591(CHEMBL203513 | [2-chloro-4-(1-methyl-1H-pyrazol-3-...)
Affinity DataIC50:  1.78E+3nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50177592((5,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-6...)
Affinity DataIC50:  5.95E+3nMAssay Description:Displacement of [3H]AVP from human V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50119187(CHEMBL431048 | N-(5-{(S)-3-[(1-{4-[3-(2,5-Difluoro...)
Affinity DataIC50:  6.16E+3nMAssay Description:Compound was tested for the antagonistic activity against Beta-1 adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 139 total ) | Next | Last >>
Jump to: