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Found 1762 with Last Name = 'steinhuebel' and Initial = 'd'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50433561(CHEMBL2381408)
Affinity DataKi:  0.880nMAssay Description:Binding affinity to recombinant human His6-tagged HDM2 (1 to 118 residues) assessed as reduction in PMDM6-F binding incubated for 15 to 30 mins by fl...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227653(3-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...)
Affinity DataIC50:  0.156nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227651(6-(5-chloropyridin-3-yl)- 8-[1-fluoro-1-(2- fluoro...)
Affinity DataIC50:  0.176nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385819(CHEMBL2043325)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385782(CHEMBL2041169)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50604556(CHEMBL5175703)
Affinity DataIC50:  0.200nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385788(CHEMBL2041175)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385796(CHEMBL2041182)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385830(CHEMBL2041185)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385799(CHEMBL2041186)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385803(CHEMBL2041190)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385805(CHEMBL2041192)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385814(CHEMBL2043169)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385819(CHEMBL2043325)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385782(CHEMBL2041169)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385796(CHEMBL2041182)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385830(CHEMBL2041185)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385803(CHEMBL2041190)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385806(CHEMBL2041193)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50095475(CHEMBL3590479)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385788(CHEMBL2041175)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385798(CHEMBL2041184)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223046(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...)
Affinity DataIC50:  0.202nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224125(3-{6-[3-chloro-5- (hydroxymethyl)phen- yl]-7-[(tra...)
Affinity DataIC50:  0.205nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224261(3-{8-[(2r)-4-acetyl- 2-phenylpiperazin-1- yl]-6-{[...)
Affinity DataIC50:  0.215nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227665(5-{6-(5-chloropyridin-3- yl)-8-[1-(2,6- difluoroph...)
Affinity DataIC50:  0.289nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385813(CHEMBL2043168)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385826(CHEMBL2041010)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385798(CHEMBL2041184)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385799(CHEMBL2041186)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385801(CHEMBL2041188)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50509399(CHEMBL4468010)
Affinity DataIC50:  0.300nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50095470(CHEMBL3590474 | US10155765, Example 9)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50095474(CHEMBL3590478 | US10329294, Example 2)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human IRAK4 assessed as phosphorylation of fluorescent peptide substrate after 30 mins by fluorescent polarization readerMore data for this Ligand-Target Pair
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385820(CHEMBL2043326)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385791(CHEMBL2041178)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385805(CHEMBL2041192)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227683(3-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...)
Affinity DataIC50:  0.315nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223705(3-(6-{[(1r)-1- cyclobutylethyl]amino}- 8- (hexahyd...)
Affinity DataIC50:  0.344nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM227669(5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- flu...)
Affinity DataIC50:  0.359nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223402(6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- m...)
Affinity DataIC50:  0.381nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385813(CHEMBL2043168)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385814(CHEMBL2043169)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385818(CHEMBL2043324)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385801(CHEMBL2041188)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385811(CHEMBL2043010)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of FLAG-tagged PHD2 expressed in baculovirus infected insect sf9 cells using biotinyl-DLDLEMLAPYIPMDDDFQL as substrate preincubated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385818(CHEMBL2043324)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385825(CHEMBL2040897)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50385797(CHEMBL2041183)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PHD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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