Compile Data Set for Download or QSAR
maximum 50k data
Found 84 with Last Name = 'stenmark' and Initial = 'p'
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581300((2S)-2-[(6-cyclopropoxy-5-{[(2,4- diamino-6-oxo-1,...)
Affinity DataIC50:  3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581306((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581317((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  5nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581313((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  8nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581288((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  10nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581298((2S)-4- [(benzenesulfonyl)carbamoyl]-2- [(5-{[(2,4...)
Affinity DataIC50:  11nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581286((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  12nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581314((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  13nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581308((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  14nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581287((2S)-2-[(3-chloro-5-{[(2,4-diamino- 6-oxo-1,6-dihy...)
Affinity DataIC50:  15nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581294((2S)-2-cyclohexyl-2-[(5-{[(2,4- diamino-6-oxo-1,6-...)
Affinity DataIC50:  17nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150038(CHEMBL3771346)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581285((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  19nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150044(CHEMBL3771039)
Affinity DataIC50:  21nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581297((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  23nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581283((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  24nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150112(CHEMBL3769835)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581307((2R)-2-[(4S)-4-carboxy-4-[(5- {[(2,4-diamino-6-oxo...)
Affinity DataIC50:  30nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581299((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  32nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150043(CHEMBL3769727)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581296((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  36nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150036(CHEMBL3771227)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581305((2S)-2-[(4S)-4-carboxy-4-[(5- {[(2,4-diamino-6-oxo...)
Affinity DataIC50:  43nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581311((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  44nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150051(CHEMBL3770446)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150040(CHEMBL3771237)
Affinity DataIC50:  46nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581293((2S)-3-cyclopentyl-2-[(5-{[(2,4- diamino-6-oxo-1,6...)
Affinity DataIC50:  46nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150052(CHEMBL3771105)
Affinity DataIC50:  47nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581292((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  49nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150035(CHEMBL3769687)
Affinity DataIC50:  49nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581291((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  53nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150026(CHEMBL3771138)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581316((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  60nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581309((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  65nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581284((2S)-2-[(5-{[(2,4-diamino-6-oxo- 1,6-dihydropyrimi...)
Affinity DataIC50:  68nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581301((2S)-2-({3-chloro-5-[2-(2,4- diamino-6-oxo-1,6- di...)
Affinity DataIC50:  72nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150039(CHEMBL3769653)
Affinity DataIC50:  73nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150114(CHEMBL3770789)
Affinity DataIC50:  74nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150049(CHEMBL3770659)
Affinity DataIC50:  75nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150050(CHEMBL3770096)
Affinity DataIC50:  82nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150053(CHEMBL3770930)
Affinity DataIC50:  85nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581315((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581310((2S)-2-[(4S)-4-carboxy-4-({5-[2- (2,4-diamino-6-ox...)
Affinity DataIC50:  92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150041(CHEMBL3770808)
Affinity DataIC50:  95nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150115(CHEMBL3770403)
Affinity DataIC50:  96nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581295((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  103nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Stockholm University

Curated by ChEMBL
LigandPNGBDBM50241669(CHEMBL4083139)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant His-tagged MTH1 expressed in Escherichia coli BL21 using dGTP as substrate after 15 mins by malachite green reagent-b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150042(CHEMBL3770193)
Affinity DataIC50:  133nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Homo sapiens (Human))
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandPNGBDBM581289((2S)-2-({5-[2-(2,4-diamino-6-oxo- 1,6-dihydropyrim...)
Affinity DataIC50:  154nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetdCTP pyrophosphatase 1(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM50150037(CHEMBL3770701)
Affinity DataIC50:  165nMAssay Description:Inhibition of human recombinant full length dCTPase expressed in Escherichia coli BL21(DE3)pLysS using dCTP as substrate after 1 hr by HTS-adapted Ma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 84 total ) | Next | Last >>
Jump to: