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Found 175 with Last Name = 'stevens' and Initial = 'mf'
TargetAryl hydrocarbon receptor(Rattus norvegicus)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50240990(2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole | 5-...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]tetrachlorodibenzo-p-dioxin from aryl hydrocarbon receptor in CRL:WI rat liver cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058420((methylbenzoprim, MBP) 5-[4-(Benzyl-methyl-amino)-...)
Affinity DataIC50:  3.20nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  10nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058408(5-(4-Chloro-3-nitro-phenyl)-6-ethyl-pyrimidine-2,4...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058408(5-(4-Chloro-3-nitro-phenyl)-6-ethyl-pyrimidine-2,4...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50029765(2-Chloro-5-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-be...)
Affinity DataIC50:  23nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAryl hydrocarbon receptor(Rattus norvegicus)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50240990(2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole | 5-...)
Affinity DataIC50:  25nMAssay Description:Displacement of [3H]tetrachlorodibenzo-p-dioxin from aryl hydrocarbon receptor in CRL:WI rat liver cytosolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50029765(2-Chloro-5-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-be...)
Affinity DataIC50:  32nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  42nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102505(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4,5-t...)
Affinity DataIC50:  70nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102506(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4-dim...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058420((methylbenzoprim, MBP) 5-[4-(Benzyl-methyl-amino)-...)
Affinity DataIC50:  91nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058401(2,4-Diamino-5-[4-chloro-3-[3-[2-(acetyloxy)ethyl]-...)
Affinity DataIC50:  170nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50029765(2-Chloro-5-(2,4-diamino-6-ethyl-pyrimidin-5-yl)-be...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058399(5-[4-Chloro-3-(morpholin-4-ylazo)-phenyl]-6-ethyl-...)
Affinity DataIC50:  190nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102520(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102503(2,4-Diamino-5-{3-[3-[2-benzoyloxy)ethyl]-3-benzyl-...)
Affinity DataIC50:  220nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50108803(3,11-dichloro-6,8,13-trimethyl-8H-quino[4,3,2-kl]a...)
Affinity DataIC50:  250nMAssay Description:Inhibition of telomerase activity using TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50108806(3,6,8,11,13-pentamethyl-8H-quino[4,3,2-kl]acridin-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of telomerase activity using TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058397(2,4-Diamino-5-[3-[3-benzyl-3-(2-hydroxyethyl)triaz...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102520(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  280nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058394(CHEMBL49246 | CHEMBL56311 | ethanesulfonic salt of...)
Affinity DataIC50:  310nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058394(CHEMBL49246 | CHEMBL56311 | ethanesulfonic salt of...)
Affinity DataIC50:  310nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50108802(3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]a...)
Affinity DataIC50:  330nMAssay Description:Inhibition of telomerase activity using TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM94892(5-(3-azido-4-chloranyl-phenyl)-6-ethyl-pyrimidine-...)
Affinity DataIC50:  330nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50087446(3-[3-(Benzothiazol-2-ylsulfanyl)-4-hydroxy-5-metho...)
Affinity DataIC50:  350nMAssay Description:Inhibition of c-erbB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102514(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,5-dim...)
Affinity DataIC50:  378nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50108805(8,13-Dimethyl-8H-8-aza-13-azonia-dibenzo[a,de]anth...)
Affinity DataIC50:  380nMAssay Description:Inhibition of telomerase activity using TRAP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  390nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM18512(5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine |...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102506(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4-dim...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058400(2,4-Diamino-5-[4-chloro-3-[3-(2-hydroxyethyl)-3-pr...)
Affinity DataIC50:  440nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058423(2,4-Diamino-5-[4-chloro-3-[3,3-bis(2-hydroxyethyl)...)
Affinity DataIC50:  440nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102515(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-metho...)
Affinity DataIC50:  440nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102505(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(3,4,5-t...)
Affinity DataIC50:  450nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058404(2,4-Diamino-5-[4-chloro-3-[3-(1,3-dioxol-2-ylmethy...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058410(CHEMBL56169 | CHEMBL57610 | methanesulfonic salt o...)
Affinity DataIC50:  570nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058404(2,4-Diamino-5-[4-chloro-3-[3-(1,3-dioxol-2-ylmethy...)
Affinity DataIC50:  570nMAssay Description:In vitro inhibitory concentration against Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102518(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(naphth-...)
Affinity DataIC50:  620nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102519(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-methy...)
Affinity DataIC50:  630nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102510(2,4-Diamino-5-{3-[3-[2-acetyloxy)ethyl]-3-(4-pyrid...)
Affinity DataIC50:  640nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102507(2,4-Diamino-5-{3-[3-benzyl-3-[2-(isobutyryloxy)eth...)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058401(2,4-Diamino-5-[4-chloro-3-[3-[2-(acetyloxy)ethyl]-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM94892(5-(3-azido-4-chloranyl-phenyl)-6-ethyl-pyrimidine-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50058401(2,4-Diamino-5-[4-chloro-3-[3-[2-(acetyloxy)ethyl]-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory concentration against Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102503(2,4-Diamino-5-{3-[3-[2-benzoyloxy)ethyl]-3-benzyl-...)
Affinity DataIC50:  690nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
University Of Nottingham

Curated by ChEMBL
LigandPNGBDBM50102502(2,4-Diamino-5-{3-[3-benzyl-3-[2-(propionyloxy)ethy...)
Affinity DataIC50:  700nMAssay Description:Inhibitory activity against dihydrofolate reductase DHFR in Toxoplasma gondii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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