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Found 24 with Last Name = 'stewart' and Initial = 'c'
TargetRenin(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50006844((S)-N-[(S)-2-(2-Amino-thiazol-4-yl)-1-((1S,2R,3S)-...)
Affinity DataIC50:  0.320nMAssay Description:Inhibitory activity of the compound against renin was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50096154(4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-6b-...)
Affinity DataIC50:  1.40nMAssay Description:Affinity for human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50096153(4b,12-Difluoro-5-hydroxy-4a,6a-dimethyl-6b-(2-oxo-...)
Affinity DataIC50:  6.40nMAssay Description:Affinity for human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50225999(1-fluoro-2-(3-pyridinyl)-ethylidene-1,1-bisphospho...)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50138725((1-phosphono-2-pyridin-3-yl-ethyl)-phosphonic acid...)
Affinity DataIC50:  34.2nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50225995(1-chloro-2-(3-pyridinyl)-ethylidene-1,1-bisphospho...)
Affinity DataIC50:  94.6nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50418088(7-ETHYL-10-HYDROXY-CAMPTOTHECIN)
Affinity DataIC50:  176nMAssay Description:TP_TRANSPORTER: drug resistance(Imatinib mesylate) in BCRP-expressing SaoS2 cellsMore data for this Ligand-Target Pair
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50240870(CHEMBL4068259)
Affinity DataIC50:  210nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50240870(CHEMBL4068259)
Affinity DataIC50:  240nMAssay Description:Inhibition of Serratia marcescens IMP1 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50096155(2-(4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-...)
Affinity DataIC50:  289nMAssay Description:Affinity for human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50225997(1-bromo-2-(3-pyridinyl)-ethylidene-1,1-bisphosphon...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50096156(2-(4b,12-Difluoro-5-hydroxy-4a,6a-dimethyl-2-oxo-8...)
Affinity DataIC50:  400nMAssay Description:Affinity for human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM25308((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...)
Affinity DataIC50:  670nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM26116(CHEMBL284104 | Dipicolinate | pyridine carboxylate...)
Affinity DataIC50:  1.66E+3nMAssay Description:Inhibition of Pseudomonas aeruginosa VIM2 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM26116(CHEMBL284104 | Dipicolinate | pyridine carboxylate...)
Affinity DataIC50:  3.03E+3nMAssay Description:Binding affinity at 5-hydroxytryptamine 1A receptor by the displacement of [3H]8-OH-DPAT in rat brain.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50318032((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50226001(2-bromo-3-(3-pyridinyl)-2-phosphonopropionic acid ...)
Affinity DataIC50: >6.00E+4nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)
Affinity DataIC50:  2.54E+5nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50225998(2-chloro-3-(3-pyridinyl)-2-phosphonopropionic acid...)
Affinity DataIC50: >6.00E+5nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50226000(2-fluoro-3-(3-pyridinyl)-2-phosphonopropionic acid...)
Affinity DataIC50: >6.00E+5nMAssay Description:Inhibition of human cloned FPPS expressed in Escherichia col BL2 (DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50318032((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50318032((+)-2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosp...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of GGPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFarnesyl pyrophosphate synthase(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM50226002((R)-2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of human FPPS after 10 mins using [14C]IPP as substrate by liquid scintillation countingChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed