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Found 104 with Last Name = 'stier' and Initial = 'm'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205450((S)-7-(3-(aminomethyl)pyrrolidin-1-yl)-1-cycloprop...)
Affinity DataKi:  2.40E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205452(7-(3-(aminomethyl)-3-ethylazetidin-1-yl)-1-cyclopr...)
Affinity DataKi:  4.50E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205465(7-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl)-1-cycl...)
Affinity DataKi:  5.10E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205451(7-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl)-1-cycl...)
Affinity DataKi:  6.20E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205466((S)-7-(3-(aminomethyl)pyrrolidin-1-yl)-1-cycloprop...)
Affinity DataKi:  6.40E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205457(7-((R)-3-((S)-1-(2-cyanoethylamino)ethyl)pyrrolidi...)
Affinity DataKi:  7.20E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205453(7-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl)-1-cycl...)
Affinity DataKi:  8.50E+4nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205446(7-((R)-3-((S)-1-(2-cyanoethylamino)ethyl)pyrrolidi...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205447(10-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl)-9-flu...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205461((S)-7-(3-((2-cyanoethylamino)methyl)pyrrolidin-1-y...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205459((S)-7-(3-(aminomethyl)pyrrolidin-1-yl)-1-cycloprop...)
Affinity DataKi:  1.06E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205455(7-(3-(aminomethyl)-3-methylazetidin-1-yl)-1-cyclop...)
Affinity DataKi:  1.12E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205449(10-((R)-3-((S)-1-amino-2-cyanoethyl)pyrrolidin-1-y...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50131445((3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205448(7-(3-((2-cyanoethylamino)methyl)-3-ethylazetidin-1...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205454(10-((R)-3-((S)-2-cyano-1-(methylamino)ethyl)pyrrol...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205467(7-(3-((2-cyanoethylamino)methyl)-3-methylazetidin-...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205464(7-((R)-3-((S)-1-amino-2-cyanoethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205460(7-((R)-3-((S)-2-cyano-1-(methylamino)ethyl)pyrroli...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205458(7-((R)-3-((S)-1-amino-2-cyanoethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205463(7-((R)-3-((S)-1-(2-cyanoethylamino)ethyl)pyrrolidi...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205462(1-cyclopropyl-6-fluoro-8-methoxy-7-((R)-3-((S)-1-(...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50205456(10-((R)-3-((S)-1-(2-cyanoethylamino)ethyl)pyrrolid...)
Affinity DataKi: >1.50E+5nMAssay Description:Displacement of [3H]dofetilide from human ERG by fliter binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50:  0.0670nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18033(Ketopiperazine-based inhibitor, 13)
Affinity DataIC50:  0.180nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18025(2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]prop...)
Affinity DataIC50:  0.420nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18032(Ketopiperazine-based inhibitor, 12)
Affinity DataIC50:  0.680nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18028((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50:  3.20nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18022(Ketopiperazine-based inhibitor, 2)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50016033(CHEMBL3085574 | {1-[1-{1-[2-(1-Benzylcarbamoyl-3-m...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18031(CHEMBL193816 | Ketopiperazine-based inhibitor, 11)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18026(2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]prop...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25437((trifluoromethyl)benzonitrile, 14 | 4-{[(1R,2S)-2-...)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50221436(4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzo...)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50016034((4-{3-[1-(4-Aminomethyl-benzylcarbamoyl)-3-methyl-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18029((6R)-6-({[1-(3-hydroxypropyl)-1,2,3,4-tetrahydroqu...)
Affinity DataIC50:  37nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50221435(4-((trans)-2-cyanocyclohexyloxy)-2-(trifluoromethy...)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]DHT from androgen receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50221436(4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzo...)
Affinity DataIC50:  58nMAssay Description:Displacement of [3H]DHT from androgen receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM25437((trifluoromethyl)benzonitrile, 14 | 4-{[(1R,2S)-2-...)
Affinity DataIC50:  60nMAssay Description:Displacement of [3H]DHT from androgen receptor expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50016025(CHEMBL354821 | {1-Benzyl-4-[3-(1-benzylcarbamoyl-3...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50016046(CHEMBL167426 | {1-Benzyl-4-[3-(1-benzylcarbamoyl-3...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18019(6-ethyl-2,4-diaminopyrimidine-based compound, 14 |...)
Affinity DataIC50:  91nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18018(6-ethyl-2,4-diaminopyrimidine-based compound, 13 |...)
Affinity DataIC50:  120nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM50016026(CHEMBL424543 | [1-(1-{1-[2-(1-Benzylcarbamoyl-3-me...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against human reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18020(6-ethyl-2,4-diaminopyrimidine-based compound, 15 |...)
Affinity DataIC50:  178nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50221435(4-((trans)-2-cyanocyclohexyloxy)-2-(trifluoromethy...)
Affinity DataIC50:  196nMAssay Description:Antagonist activity at androgen receptor expressed in MDA-MB-453 cells assessed as inhibition of dihydrotestosterone-induced response in reporter gen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18017(6-ethyl-2,4-diaminopyrimidine-based compound, 12 |...)
Affinity DataIC50:  198nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Pfizer

Curated by ChEMBL
LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197073(3-amino-7-((R)-3-((S)-1-aminoethyl)pyrrolidin-1-yl...)
Affinity DataIC50:  200nMAssay Description:Inhibition of Escherichia coli gyraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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