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Found 120 with Last Name = 'stonehouse' and Initial = 'jp'
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371784(CHEMBL446458)
Affinity DataIC50:  1nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065327(CHEMBL3403851)
Affinity DataIC50:  2.5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065330(CHEMBL3403854)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50371783(CHEMBL397237)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065326(CHEMBL3403850)
Affinity DataIC50:  4nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065324(CHEMBL3403848)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065331(CHEMBL3403855)
Affinity DataIC50:  5nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312172(Alternative Preparation | US10016430, Example 3 | ...)
Affinity DataIC50:  7nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312171(1-[2-(1-Aminoethyl)-4-chlorobenzyl]-2-thioxo-1,2,3...)
Affinity DataIC50:  7nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065328(CHEMBL3403852)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065325(CHEMBL3403849)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065329(CHEMBL3403853)
Affinity DataIC50:  7.90nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  8.60nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  8.60nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312157(1-{2-[(1R)-1-Aminopropyl]-4-chlorobenzyl}-2-thioxo...)
Affinity DataIC50:  8.60nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065267(CHEMBL3403840)
Affinity DataIC50:  10nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312256(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)
Affinity DataIC50:  10nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312256(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)
Affinity DataIC50:  10nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312256(1-{2-[(Cyclobutylamino)methyl]benzyl}-2-thioxo-1,2...)
Affinity DataIC50:  10nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50:  13nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065256(CHEMBL3403835)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065323(CHEMBL3403847)
Affinity DataIC50:  13nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50:  13nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312245(1-{4-Chloro-2-[(methylamino)methyl]benzyl}-2-thiox...)
Affinity DataIC50:  13nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312257(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  14nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312257(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  14nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312257(1-{2-[(Cyclopentylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  14nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50:  15nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50:  15nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312244(1-[2-(Aminomethyl)-4-chlorobenzyl]-2-thioxo-1,2,3,...)
Affinity DataIC50:  15nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Affinity DataIC50:  19nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Affinity DataIC50:  19nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312176(1-{4-Chloro-2-[1-(methylamino)ethyl]benzyl}-2-thio...)
Affinity DataIC50:  19nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312243(1-{4-Chloro-2-[(ethylamino)methyl]benzyl}-2-thioxo...)
Affinity DataIC50:  22nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312261(1-{2-[(Propan-2-ylamino)methyl]benzyl}-2-thioxo-1,...)
Affinity DataIC50:  24nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065270(CHEMBL3403843)
Affinity DataIC50:  25nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312251(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)
Affinity DataIC50:  29nMAssay Description:The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312251(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)
Affinity DataIC50:  29nMAssay Description:Methods for the determination of MPO inhibitory activity are disclosed in WO 02/090575. The pharmacological activity of compounds disclosed herein wa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyeloperoxidase(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM312251(1-(2-{[(Cyclobutylmethyl)amino]methyl}benzyl)-2-th...)
Affinity DataIC50:  29nMAssay Description:MPO: The pharmacological activity of compounds disclosed herein was tested in the following screen (Test A) in which the compounds were tested in the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065269(CHEMBL3403842)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065254(CHEMBL3403834)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50065322(CHEMBL3403846)
Affinity DataIC50:  32nMAssay Description:Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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