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Found 99 with Last Name = 'stout' and Initial = 'm'
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302101(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Affinity DataKi:  110nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataKi:  120nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50354833(AGF94 | CHEMBL1834488)
Affinity DataKi:  130nMpH: 5.5Assay Description:Inhibition of human PCFT-mediated [3H]MTX uptake expressed in chinese hamster R2 cells at pH 5.5 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302104(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Affinity DataKi:  130nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302103(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Affinity DataKi:  180nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302106(3-(2-(2-ethyl-2-(4-fluorobenzoyl)hydrazinyl)-3,4-d...)
Affinity DataKi:  260nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302100(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Affinity DataKi:  320nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302102(3-(2-(2-ethyl-2-(4-fluorophenyl)hydrazinyl)-3,4-di...)
Affinity DataKi:  550nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50354833(AGF94 | CHEMBL1834488)
Affinity DataKi:  1.82E+3nMpH: 6.8Assay Description:Inhibition of human PCFT-mediated [3H]MTX uptake expressed in chinese hamster R2 cells at pH 6.8 by dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302101(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Affinity DataKi:  4.10E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302104(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Affinity DataKi:  5.20E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302103(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Affinity DataKi:  6.50E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302105(3-(2-(2-ethyl-2-(4-fluorobenzyl)hydrazinyl)-3,4-di...)
Affinity DataKi:  7.20E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataKi:  9.70E+3nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302106(3-(2-(2-ethyl-2-(4-fluorobenzoyl)hydrazinyl)-3,4-d...)
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302105(3-(2-(2-ethyl-2-(4-fluorobenzyl)hydrazinyl)-3,4-di...)
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302100(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 1(Homo sapiens (Human))
Wuxi Pharmatech

Curated by ChEMBL
LigandPNGBDBM50302102(3-(2-(2-ethyl-2-(4-fluorophenyl)hydrazinyl)-3,4-di...)
Affinity DataKi: >1.20E+4nMAssay Description:Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM10989((1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-ami...)
Affinity DataIC50:  4nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057114((2-Benzooxazol-6-yl-ethyl)-((R)-5-methoxy-1,2,3,4-...)
Affinity DataIC50:  5.25nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057102(CHEMBL10410 | [2-(2-Methanesulfonyl-2,3-dihydro-1H...)
Affinity DataIC50:  5.81nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataIC50:  6.43nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057099(CHEMBL9970 | [2-(2,2-Dioxo-2,3-dihydro-1H-2lambda*...)
Affinity DataIC50:  6.67nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057101((2-Benzothiazol-6-yl-ethyl)-((R)-5-methoxy-1,2,3,4...)
Affinity DataIC50:  8.94nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057108(6-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataIC50:  9.47nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057135(CHEMBL9896 | [2-(1H-Benzoimidazol-5-yl)-ethyl]-((R...)
Affinity DataIC50:  11.3nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057124(CHEMBL430314 | [2-(2,3-Dihydro-1H-isoindol-5-yl)-e...)
Affinity DataIC50:  11.6nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057098((2-Benzo[1,3]dioxol-5-yl-ethyl)-((R)-5-methoxy-1,2...)
Affinity DataIC50:  12.7nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057128((2-Benzofuran-6-yl-ethyl)-((R)-5-methoxy-1,2,3,4-t...)
Affinity DataIC50:  13.1nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057113(CHEMBL9912 | [2-(2,3-Dihydro-benzofuran-5-yl)-ethy...)
Affinity DataIC50:  14.6nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057110(5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataIC50:  16.3nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057104((2-Benzooxazol-5-yl-ethyl)-((R)-5-methoxy-1,2,3,4-...)
Affinity DataIC50:  16.7nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057142((2-Benzofuran-5-yl-ethyl)-((R)-5-methoxy-1,2,3,4-t...)
Affinity DataIC50:  17.6nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057125(CHEMBL274391 | [2-(2,3-Dihydro-benzofuran-6-yl)-et...)
Affinity DataIC50:  18.1nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057145(((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylm...)
Affinity DataIC50:  18.1nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057131(6-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataIC50:  19.4nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM158502(US9034303, Compound 3)
Affinity DataIC50:  20nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057129((2-Indan-5-yl-ethyl)-((R)-5-methoxy-1,2,3,4-tetrah...)
Affinity DataIC50:  20.5nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057093((2-Benzo[1,3]dioxol-5-yl-ethyl)-(5-methoxy-1,2,3,4...)
Affinity DataIC50:  20.6nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057095(5-{2-[((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen...)
Affinity DataIC50:  22.2nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057112(CHEMBL10369 | [2-(2,3-Dihydro-benzo[b]thiophen-5-y...)
Affinity DataIC50:  24.3nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057126((2-Benzo[1,3]dioxol-5-yl-ethyl)-[(R)-1-(2,3,6,7,8,...)
Affinity DataIC50:  26.7nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM158501(US9034303, O-Methyl-M30)
Affinity DataIC50:  30nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057141(CHEMBL276236 | [2-(2,3-Dihydro-1H-indol-5-yl)-ethy...)
Affinity DataIC50:  31.8nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057111(CHEMBL10066 | [2-(1,1-Dioxo-2,3-dihydro-1H-1lambda...)
Affinity DataIC50:  33.7nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057092(CHEMBL10170 | [2-(1-Methanesulfonyl-2,3-dihydro-1H...)
Affinity DataIC50:  35nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM36551(Chelator, M30 | US9034303, M30)
Affinity DataIC50:  37nMAssay Description:MAO-A and MAO-B activity was measured using radioactive substrates. The substrate for MAO-A was 5 HT and for MAO-B was PEA. When measuring the activi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057146(CHEMBL418337 | [2-(2-Chloro-benzothiazol-6-yl)-eth...)
Affinity DataIC50:  38.2nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057147(CHEMBL269402 | [2-(1-Methanesulfonyl-2,3-dihydro-1...)
Affinity DataIC50:  38.9nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50057105(((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-ylm...)
Affinity DataIC50:  42.8nMAssay Description:Inhibition of uptake of [3H]-5-HT in synaptosomes from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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