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Found 125 with Last Name = 'strasser' and Initial = 'ds'
TargetC-X-C chemokine receptor type 3(Mus musculus)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Rattus norvegicus)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  2.20nMAssay Description:Antagonist activity at rat CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50613175(CHEMBL5269745)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Canis familiaris)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM610444(2-(3-Ethyl-pyrazol-1-yl)-1-{(R)-2-(2-hydroxy-ethyl...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  3.20nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL10 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL9 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50613174(CHEMBL5284001)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Canis familiaris)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at dog CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Mus musculus)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  4.40nMAssay Description:Antagonist activity at mouse CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
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LigandPNGBDBM610443(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613180(CHEMBL5287805)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  5.30nMAssay Description:Antagonist activity at human CXCR3 expressed in CHO-K1 cells assessed as reduction in CXCL11 induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
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LigandPNGBDBM610438(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613172(CHEMBL5274429)
Affinity DataIC50:  7nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610435(2-(3-Cyclopropyl-[1,2,4]triazol-1-yl)-1-{(R)-2-(2-...)
Affinity DataIC50:  7.30nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613173(CHEMBL5277205)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human ERG K+ currents by GLP assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610448(2-(3-Ethyl-pyrazol-1-yl)-1-{(S)-2-hydroxymethyl-4-...)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613165(CHEMBL5290851)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610436(2-(3-Ethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-(2-hydrox...)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary human T cells assessed as inhibition of CXCLI1 mediate...More data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Mus musculus)TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at mouse CXCR3-mediated chemotaxis expressed in CD3/CD28-activated primary mouse T cells assessed as inhibition of CXCLI1 mediate...More data for this Ligand-Target Pair
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LigandPNGBDBM50613187(CHEMBL5271152)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613169(CHEMBL5276329)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613166(CHEMBL5290634)
Affinity DataIC50:  12nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613170(CHEMBL5268766)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610446(1-{(S)-2-Hydroxymethyl-4-[2-trifluoromethyl-4-(2-t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613168(CHEMBL5273485)
Affinity DataIC50:  16nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613167(CHEMBL5274784)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610415(1-{(R)-2-Hydroxymethyl-4-[2-trifluoromethyl-4-(2-t...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50613177(CHEMBL5276903)
Affinity DataIC50:  18nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613186(CHEMBL5269005)
Affinity DataIC50:  19nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610426(1-{(R)-2-Hydroxymethyl-4-[2-trifluoromethyl-4-(2-t...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610444(2-(3-Ethyl-pyrazol-1-yl)-1-{(R)-2-(2-hydroxy-ethyl...)
Affinity DataIC50:  25nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613185(CHEMBL5281798)
Affinity DataIC50:  27nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM610138(1-{(S)-2-Hydroxymethyl-4-[2-trifluoromethyl-4-(2-t...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610443(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
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LigandPNGBDBM610068(2-(3-Cyclopropyl-[1,2,4]triazol-1-yl)-1-{(S)-2-hyd...)
Affinity DataIC50:  31nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610448(2-(3-Ethyl-pyrazol-1-yl)-1-{(S)-2-hydroxymethyl-4-...)
Affinity DataIC50:  34nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610436(2-(3-Ethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-(2-hydrox...)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
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LigandPNGBDBM50613182(CHEMBL5272456)
Affinity DataIC50:  52nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610446(1-{(S)-2-Hydroxymethyl-4-[2-trifluoromethyl-4-(2-t...)
Affinity DataIC50:  53nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM50613180(CHEMBL5287805)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610439(1-{(R)-2-(2-Hydroxy-ethyl)-4-[2-trifluoromethyl-4-...)
Affinity DataIC50:  56nMAssay Description:Antagonist activity at CXCR3 in human whole blood assessed as receptor internalization incubated for 30 mins in presence of CXCL10 by flow cytometric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))TBA
LigandPNGBDBM610435(2-(3-Cyclopropyl-[1,2,4]triazol-1-yl)-1-{(R)-2-(2-...)
Affinity DataIC50:  59nMAssay Description:Antagonist activity at CXCR3 (unknown origin) in human T cells in venous blood assessed as receptor internalization incubated for 30 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50613184(CHEMBL5274148)
Affinity DataIC50: >60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613181(CHEMBL5277109)
Affinity DataIC50: >60nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV holding voltage by automated QPatch electrophysiological assayMore data for this Ligand-Target Pair
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