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Found 314 with Last Name = 'suchomel' and Initial = 'j'
LigandPNGBDBM50064300(CHEMBL3403664)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001577(CHEMBL3237712)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403099(CHEMBL2216892)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001541(CHEMBL3237706)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557972(CHEMBL4790186)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of recombinant full length N-terminal polyHis-tagged PI3K p110delta/p85alpha (unknown origin) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50064305(CHEMBL3403669)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403099(CHEMBL2216892)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064306(CHEMBL3403670)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001583(CHEMBL3237718)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064300(CHEMBL3403664)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064301(CHEMBL3403665)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557974(CHEMBL4762294)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of recombinant full length N-terminal polyHis-tagged PI3K p110delta/p85alpha (unknown origin) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001539(CHEMBL3237704 | US8841312, 204)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064301(CHEMBL3403665)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064296(CHEMBL3403676)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064296(CHEMBL3403676)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064304(CHEMBL3403668)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064294(CHEMBL3403674)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064295(CHEMBL3403675)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064328(CHEMBL3403671)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403096(CHEMBL2216895)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PI3Kdelta in antiIgM/CD40L-induced human B cells assessed as reduction in cell viability preincubated for 30 mins followed by antiIgM/C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50557971(CHEMBL4747926)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of recombinant full length N-terminal polyHis-tagged PI3K p110delta/p85alpha (unknown origin) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001536(CHEMBL3237451 | US8841312, 23)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001542(CHEMBL3237707)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001584(CHEMBL3237442 | US8841312, 1)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001545(CHEMBL3237710)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001538(CHEMBL3237703)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403096(CHEMBL2216895)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of recombinant full length N-terminal polyHis-tagged PI3K p110delta/p85alpha (unknown origin) expressed in baculovirus infected Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064298(CHEMBL3403678)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064306(CHEMBL3403670)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403096(CHEMBL2216895)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PI3Kdelta in Balb/c mouse B cells assessed as inhibition of antiIgM-induced Akt phosphorylation at ser 473 residue preincubated for 45 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064327(CHEMBL3403667)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
LigandPNGBDBM50557969(CHEMBL4763849)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PI3kdelta in anti-IgD-induced human whole blood cells assessed as reduction in Akt phosphorylation at ser 473 residue pretreated with c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50064303(CHEMBL3403666)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) assessed as inhibition of AKT phosphorylation by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001540(CHEMBL3237705)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001582(CHEMBL3237717)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001579(CHEMBL3237714)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50001535(CHEMBL3237450)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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