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Found 228 with Last Name = 'sugawara' and Initial = 'f'
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50448689(CHEMBL3127730)
Affinity DataKi:  5.50E+3nMAssay Description:Competitive inhibition of recombinant rat DNA polymerase beta using poly(dA)/oligo(dT)18 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of nucleotide substrate c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  9.85E+3nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50448689(CHEMBL3127730)
Affinity DataKi:  1.16E+4nMAssay Description:Noncompetitive inhibition of recombinant rat DNA polymerase beta using dTTP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)
Affinity DataKi:  1.81E+4nMAssay Description:Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)
Affinity DataKi:  2.01E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223758(CHEMBL58925)
Affinity DataIC50:  1nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223748(CHEMBL406322)
Affinity DataIC50:  4nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223740(CHEMBL431679)
Affinity DataIC50:  5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223762(CHEMBL417588)
Affinity DataIC50:  6nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223756(CHEMBL333710)
Affinity DataIC50:  14nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223759(CHEMBL118469)
Affinity DataIC50:  37nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223754(CHEMBL332885)
Affinity DataIC50:  38nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223738(CHEMBL118450)
Affinity DataIC50:  47nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223737(CHEMBL115852)
Affinity DataIC50:  57nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33388(dehydroaltenusin derivative, 16)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223757(CHEMBL291976)
Affinity DataIC50:  71nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33387(dehydroaltenusin derivative, 15)
Affinity DataIC50:  90nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223753(CHEMBL119059)
Affinity DataIC50:  140nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223749(CHEMBL332977)
Affinity DataIC50:  150nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33386(dehydroaltenusin derivative, 14)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223750(CHEMBL119731)
Affinity DataIC50:  190nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223739(CHEMBL117056)
Affinity DataIC50:  210nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33389(dehydroaltenusin derivative, 20)
Affinity DataIC50:  240nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33384(dehydroaltenusin)
Affinity DataIC50:  680nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223741(CHEMBL333173)
Affinity DataIC50:  720nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33385(desmethyldehydroaltenusin, 2)
Affinity DataIC50:  890nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223751(CHEMBL119353)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223760(CHEMBL332071)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA nucleotidylexotransferase(Homo sapiens (Human))
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50143524((3aR,4R,7R,7aS)-3,5-Dihexadecyl-3a,4,7,7a-tetrahyd...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity of the compound against human terminal deoxynucleotidyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223764(CHEMBL119757)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223765(CHEMBL420538)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223755(CHEMBL118108)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50223763(CHEMBL261984)
Affinity DataIC50: >2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 unitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory effect of the compound on the activity of rat DNA polymerase beta was determined by inhibitory dose curvesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM33388(dehydroaltenusin derivative, 16)
Affinity DataIC50:  1.10E+4nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50153117((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 unitsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University Of Science

Curated by ChEMBL
LigandPNGBDBM50375301(CHEMBL260980)
Affinity DataIC50:  1.19E+4nMAssay Description:Inhibition of rat DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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