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Found 23 with Last Name = 'surade' and Initial = 's'
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using mephenytoin as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169702(CHEMBL3805279)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169700(CHEMBL3806115)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM50169698(CHEMBL3806191)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228827(3-Cyclopentyl-1-(pyrrolidin-1-yl)propan-1-one (1))
Affinity DataKd:  1.20E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31772(1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMycocyclosin synthase(Mycobacterium tuberculosis)
University Of Cambridge

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)
Affinity DataKd:  73nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228834(3-(Furan-3-yl)-1-(pyrrolidin-1-yl)propan-1-one (8))
Affinity DataKd:  2.20E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228828(Cyclopentylmethyl pyrrolidine-1-carboxylate (2))
Affinity DataKd:  1.50E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228832(N-(Cyclopentylmethyl)pyrrolidine-1-sulfonamide (6))
Affinity DataKd:  2.00E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228831(1-((2-Cyclopentylethyl)sulfonyl)pyrrolidine (5))
Affinity DataKd:  1.60E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228830(N-(Cyclopentylmethyl)cyclopentanecarboxamide (4))
Affinity DataKd:  1.10E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228829(N-(Cyclopentylmethyl)pyrrolidine-1-carboxamide (3))
Affinity DataKd:  6.00E+3nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
TargetHTH-type transcriptional regulator EthR(Mycobacterium tuberculosis)
University of Cambridge

LigandPNGBDBM228833((E)-3-(Furan-3-yl)-1-(pyrrolidin-1-yl)prop-2-en-1-...)
Affinity DataKd:  2.00E+4nMAssay Description:An aqueous solution of the fragment to be tested (1 mM) was prepared containing NaCl (300 mM), Tris.HCl (20 mM, pH = 8.0), d6-DMSO (10% v/v) and glyc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB