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Found 111 with Last Name = 'suyama' and Initial = 'k'
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.670nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  0.720nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387580(CHEMBL2058051)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387576(CHEMBL2058047)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50251742((3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydro...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387577(CHEMBL2058048)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544710(CHEMBL4642117)
Affinity DataIC50:  7.40nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387581(CHEMBL2058052)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387574(CHEMBL2058044)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387575(CHEMBL2058045)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387578(CHEMBL2058049)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387572(CHEMBL2058053)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544710(CHEMBL4642117)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50410509(CHEMBL196585 | SJ000143975)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387571(CHEMBL2058046)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282586(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(phosphonome...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387579(CHEMBL2058050)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50:  40nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544710(CHEMBL4642117)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50410509(CHEMBL196585 | SJ000143975)
Affinity DataIC50:  43nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544707(CHEBI:72754 | CHEMBL1900054)
Affinity DataIC50:  70nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50410509(CHEMBL196585 | SJ000143975)
Affinity DataIC50:  85nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544709(CHEMBL4646249)
Affinity DataIC50:  97nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282589(2-{(S)-2-[3-(4-Hydroxy-phenyl)-1-phosphono-propyla...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282588(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-phenyl-1-...)
Affinity DataIC50:  130nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282593(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-naphthale...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544709(CHEMBL4646249)
Affinity DataIC50:  181nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338244(6-(4-fluorobenzyl)-2-ureido-5,6-dihydro-4H-thieno[...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282593(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-naphthale...)
Affinity DataIC50:  260nMAssay Description:Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50544709(CHEMBL4646249)
Affinity DataIC50:  331nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338239(7-(1-(4-amino-2-fluorobenzyl)piperidin-3-yl)-2-ure...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338237(7-(1-(4-chloro-2-fluorobenzyl)piperidin-3-yl)-2-ur...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282592(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(1-phosphono...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282587(3-(S)-1H-Indol-3-yl-2-{(S)-2-[3-(1H-indol-3-yl)-1-...)
Affinity DataIC50:  560nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEstrogen receptor beta(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29608(Bisphenol A (BPA) | Diphenylolpropane | US9688816,...)
Affinity DataIC50:  870nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338243(7-(4-fluorobenzyl)-2-ureido-5,7-dihydro-4H-thieno[...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338260(7-(1-(2-fluoro-4-hydroxybenzyl)piperidin-3-yl)-2-u...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM29608(Bisphenol A (BPA) | Diphenylolpropane | US9688816,...)
Affinity DataIC50:  904nMAssay Description:Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells in...More data for this Ligand-Target Pair
TargetEndothelin-converting enzyme 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282595(CHEMBL281562 | PO3 2-Leu-Trp-O-3K)
Affinity DataIC50:  960nMAssay Description:Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50282590(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(4-phenyl-1-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestineMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-converting enzyme 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282588(3-(S)-1H-Indol-3-yl-2-[(S)-4-methyl-2-(3-phenyl-1-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Toray Industries

Curated by ChEMBL
LigandPNGBDBM50387573(CHEMBL2058043)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282585(CHEMBL22509 | PO3 2-Nle-Trp-O-3K)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338238(7-(1-(2,4-difluorobenzyl)piperidin-3-yl)-2-ureido-...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Bos taurus)
TBA

Curated by ChEMBL
LigandPNGBDBM50282587(3-(S)-1H-Indol-3-yl-2-{(S)-2-[3-(1H-indol-3-yl)-1-...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of Endothelin-converting enzyme (ECE) from microsomal fractions of bovine cultured endothelial cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338240(7-(1-(2-fluoro-4-methoxybenzyl)piperidin-3-yl)-2-u...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338242(6-propyl-2-ureido-5,6-dihydro-4H-thieno[2,3-e]inda...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Kyorin Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50338235((+/-)-7-(1-benzylpiperidin-3-yl)-2-ureido-5,7-dihy...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of human IKK-beta by substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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