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Found 194 with Last Name = 'sypek' and Initial = 'j'
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360964(CHEMBL1935285)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360965(CHEMBL1935286)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360966(CHEMBL1935287)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360967(CHEMBL1935288)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360956(CHEMBL1935304)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360963(CHEMBL1935284)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360968(CHEMBL1935290)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295489((S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360959(CHEMBL1935280)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50:  0.900nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50026624(CHEMBL1935289)
Affinity DataIC50: <1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360969(CHEMBL1935291)
Affinity DataIC50:  1nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50:  1.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28481((2S)-3-methyl-2-{[12-({[2-(thiophen-2-yl)ethyl]car...)
Affinity DataIC50:  1.10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360970(CHEMBL1935292)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50295488((R)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  1.30nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant MMP13More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295479((S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360952(CHEMBL1935300)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295488((R)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]thiophe...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360950(CHEMBL1935298)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28469((2S)-2-({12-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295479((S)-3-Methyl-2-(8-(2-oxooxazolidin-3-yl)dibenzo[b,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28479((2S)-2-({12-[(cyclopentylcarbamoyl)amino]-8-oxatri...)
Affinity DataIC50:  2.10nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28473((2S)-2-[(12-{[(2-fluoroethoxy)carbonyl]amino}-8-ox...)
Affinity DataIC50:  2.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360962(CHEMBL1935283)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360951(CHEMBL1935299)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360953(CHEMBL1935301)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360972(CHEMBL1935294)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28480((2S)-3-methyl-2-({12-[(thiophen-3-ylcarbamoyl)amin...)
Affinity DataIC50:  3.30nMAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360955(CHEMBL1935303)
Affinity DataIC50:  4nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360947(CHEMBL1935295)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28472((2S)-3-methyl-2-[(12-{[(2-methylpropoxy)carbonyl]a...)
Affinity DataIC50:  4.70nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28470((2S)-2-({12-[(ethoxycarbonyl)amino]-8-oxatricyclo[...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM28485((2S)-2-({4-[4-(1-benzofuran-2-amido)phenyl]benzene...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28479((2S)-2-({12-[(cyclopentylcarbamoyl)amino]-8-oxatri...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28470((2S)-2-({12-[(ethoxycarbonyl)amino]-8-oxatricyclo[...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360949(CHEMBL1935297)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28471((2S)-3-methyl-2-({12-[(propoxycarbonyl)amino]-8-ox...)
Affinity DataIC50:  5.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295499((S)-2-(7-((But-3-ynyloxy)carbonylamino)dibenzo[b,d...)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295495((S)-2-(7-(Ethoxycarbonylamino)dibenzo[b,d]thiophen...)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28475((2S)-2-({12-[(2-chlorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  6.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360954(CHEMBL1935302)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28463((2R)-2-({11-[(methoxycarbonyl)amino]-8-oxatricyclo...)
Affinity DataIC50:  7.20nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28478((2S)-2-{[12-(carbamoylamino)-8-oxatricyclo[7.4.0.0...)
Affinity DataIC50:  7.60nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50295498((S)-3-Methyl-2-(7-((2-(methylsulfonyl)ethoxy)carbo...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human recombinant MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM28476((2S)-2-({12-[(4-fluorophenoxycarbonyl)amino]-8-oxa...)
Affinity DataIC50:  8.10nMpH: 7.5 T: 2°CAssay Description:The assays for human MMP activity were performed by incubating fluorogenic peptide substrate with recombinant human MMP catalytic domain along with v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50360971(CHEMBL1935293)
Affinity DataIC50:  8.60nMAssay Description:Inhibition of human MMP-12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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